The Catalan outfit recorded a 2-1 victory over Real Madrid before the international break, while Cadiz played out a goalless draw with Valencia in their last game earlier this month.
Espanyol have won two, drawn three and lost three of their opening eight matches of the season to collect nine points, which has left them in a respectable 13th position in the table heading into the next set of fixtures.
The White and Blues were relegated from La Liga at the end of 2019-20 but secured an immediate return by winning last season's Segunda Division, and they will be desperate to avoid a relegation battle this term.
Vicente Moreno's side have only actually lost one of their last four in the league and have won two of their last three, including a 2-1 success over Real Madrid before the international break.
Espanyol scored through Raul de Tomas and Aleix Vidal to move into a 2-0 lead against Real Madrid and managed to hold on for all three points despite Karim Benzema halving the deficit in the 71st minute.
The Catalan outfit have faced Cadiz on 28 previous occasions, recording 12 wins in the process, but this will be the first contest between the two teams in Spain's top flight since March 2006, when Cadiz recorded a 2-0 victory courtesy of goals from Abraham Paz and Jonathan Sesma.
Cadiz, meanwhile, excelled on their return to the top flight last season, claiming 12th, meaning that they are playing in back-to-back campaigns at this level for the first time since the early 1990s.
The Yellow Submarine have won one, drawn four and lost three of their opening eight matches of the new La Liga season to collect seven points, which has left them in 15th position in the table.
Cadiz's only victory of the season thus far came away at Celta Vigo on September 17, but they have only lost one of their last four and held Barcelona to a goalless draw towards the end of last month.
Alvaro Cervera's side entered the international break off the back of a goalless draw with Valencia, meanwhile, and will now be looking to continue an impressive run of form on the road, which has seen them lose just two of their last eight away league games, dating back to last season.
If Vidal is able to prove his fitness then there is every chance that the team could be unchanged from the one that took to the field for the first whistle against Real Madrid.
As for Cadiz, Jon Ander Garrido will miss out due to a tendon problem, but the visitors are otherwise in good shape heading into the contest.
Head coach Alvaro could also name an unchanged side from the clash with Valencia before the international break; Milutin Osmajic was handed his first start of the season against Los Che and should retain his spot alongside Alvaro Negredo in the final third of the field.
Espanyol possible starting lineup:
Diego Lopez; Gil, Gomez, Cabrera, Pedrosa; Bare; Vidal, Melendo, Darder, Embarba; De Tomas
Cadiz possible starting lineup:
Ledesma; Iza, Haroyan, Fali, Espino; Sanchez, Jonsson, Alarcon, Fernandez; Negredo, Osmajic
We say: Espanyol 2-1 Cadiz
Espanyol were impressive against Real Madrid before the international break, and we are backing Moreno's side to win again here. Cadiz have shared the points in half of their eight league matches this season but could suffer their fourth defeat of the campaign at RCDE Stadium.
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