Always a game with plenty of fascinating sub-plots, Manchester United will seek their 100th win over Arsenal in Mikel Arteta's 200th Premier League match in charge at Old Trafford on Sunday afternoon.
The Red Devils could only draw 1-1 with Real Sociedad in their Europa League last-16 first leg on Thursday, two days after the Gunners slaughtered PSV Eindhoven 7-1 in the Champions League, and here Sports Mole rounds up the team news for both teams.
MANCHESTER UNITED vs. ARSENAL
MANCHESTER UNITED
Out: Patrick Dorgu (suspended), Amad Diallo (ankle), Lisandro Martinez (knee), Kobbie Mainoo (calf), Jonny Evans (back), Luke Shaw (hamstring), Mason Mount (hamstring), Altay Bayindir (unspecified), Tom Heaton (unspecified)
Doubtful: Harry Maguire (knock), Manuel Ugarte (knock)
Sports Mole's predicted XI: Onana; Yoro, De Ligt, Lindelof; Mazraoui, Casemiro, Fernandes, Dalot; Zirkzee, Garnacho; Hojlund
ARSENAL
Out: Gabriel Martinelli (hamstring), Bukayo Saka (hamstring), Kai Havertz (hamstring), Gabriel Jesus (knee), Takehiro Tomiyasu (knee)
Doubtful: None
Sports Mole's predicted XI: Raya; Timber, Saliba, Gabriel, Lewis-Skelly; Odegaard, Partey, Rice; Nwaneri, Merino, Trossard
For data analysis of the most likely results, scorelines and more for this match please click here.
