Spurs finished fourth in England's top flight last term, while Southampton were 15th, and here Sports Mole rounds up the team news ahead of their clash in London this weekend.
Doubtful: Yves Bissouma (hamstring)
Sports Mole's predicted XI: Lloris; Romero, Dier, Davies; Doherty, Hojbjerg, Bentancur, Sessegnon; Kulusevski, Kane, Son
Sports Mole's predicted XI: Bazunu; Walker-Peters, Salisu, Bednarek, Perraud; S Armstrong, Ward-Prowse, Romeu, Elyounoussi; Aribo; Adams
For data analysis of the most likely results, scorelines and more for this match please click here.