Elche vs. Sevilla (Wednesday, 6.30pm)
Sevilla will be looking to continue their ascent of the La Liga table when they face bottom club Elche at the Estadio Manuel Martinez Valero on Wednesday evening.
Thanks to a stunning upturn under Jose Luis Mendilibar, Sevilla find themselves two points shy of the European places, while already-relegated Elche are 14 points adrift at the foot of the standings.
We say: Elche 0-2 Sevilla
Despite Elche's recent upturn, we expect Sevilla to continue their revival under Mendilibar by securing a straightforward win on Wednesday, achieving a fifth successive away league victory in the process.
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Villarreal vs. Cadiz (Wednesday, 6.30pm)
La Liga's Yellow Submarines will do battle at El Madrigal on Wednesday night, as Champions League-chasing Villarreal host relegation-threatened Cadiz.
Villarreal cemented fifth place in the table with a last-gasp victory at Girona last time out, while Cadiz enhanced their survival hopes with a pivotal win over Real Valladolid.
We say: Villarreal 3-0 Cadiz
Given Villarreal's recent run of high-scoring home wins, we expect Setien's men to secure a fifth victory in six matches at the expense of Cadiz, who are on course to suffer a third consecutive away defeat.
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Real Madrid vs. Rayo Vallecano (Wednesday, 6.30pm)
Seeking to avoid a third successive defeat in all competitions, Real Madrid welcome Rayo Vallecano to the Santiago Bernabeu for a La Liga clash on Wednesday evening.
Los Blancos will be seeking revenge against their fellow Madrid-based counterparts after suffering a 3-2 defeat in the reverse fixture at the Estadio de Vallecas in November last year.
We say: Real Madrid 3-1 Rayo Vallecano
Both teams will be keen to bounce back from defeats last weekend and claim maximum points in their quests to achieve their respective targets in the final three games of the campaign.
Rayo Vallecano will fancy their chances of causing another upset against Real Madrid, but we believe the hosts will continue their strong form on home soil and come out on top on Wednesday, even without the presence of Vinicius in attack.
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> How Real Madrid could line up against Rayo Vallecano
> Real Madrid injury, suspension list vs. Vallecano
Betis vs. Getafe (Wednesday, 9.00pm)
Having failed to create some breathing space in their battle against La Liga relegation last time out, Getafe take to the road to meet European hopefuls Real Betis at Estadio Benito Villamarin on Wednesday.
Manuel Pellegrini's side held local rivals Sevilla to a goalless stalemate in their most recent affair, while their visitors also shook hands on a point in a 1-1 draw with Elche.
We say: Real Betis 1-0 Getafe
With neither side displaying a propensity for ruthless finishing, goals ought to be at a premium at Estadio Benito Villamarin, where a wealth of changes from the hosts should also hamper their attacking prowess.
Getafe historically struggle for inspiration in the final third against the Verdiblancos, though, and with Bordalas's side continuing to come up short on their travels, Betis can eke out a slender win to keep their hopes of a top-five finish alive while simultaneously harming Getafe's survival chances further.
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Espanyol vs. Atletico (Wednesday, 9.00pm)
On the back of a potentially priceless win at the weekend, relegation-battling Espanyol welcome Atletico Madrid to the RCDE Stadium for Wednesday night's La Liga showdown.
The hosts saw off Rayo Vallecano 2-1 at the weekend in a major boost to their survival prospects, while Diego Simeone's men cruised past Osasuna 3-0.
We say: Espanyol 1-3 Atletico Madrid
Both sides have found the back of the net in the last five meetings between Espanyol and Atletico Madrid, and such a sequence should certainly continue on Wednesday given their respective penchants for goalscoring.
The hosts certainly have more to play for than their podium-chasing visitors at this stage, but their lingering defensive concerns should prove fatal against a rampant Atletico crop, who should right the wrongs of their loss to Elche with a resounding win to plunge Espanyol back into demotion danger.
