Orlando City vs. Montreal (Sunday, 6.00pm)
Both teams had an up-and-down campaign last year, with The Lions finishing sixth in the Eastern Conference thanks to a 2-0 victory over Montreal, who missed the playoffs by two points.
We say: Orlando City 0-1 CF Montreal
Atlanta vs. Kansas (Sunday, 8.00pm)
Despite a tumultuous early 2021 campaign, The Five Stripes managed to make it back into the postseason, losing 2-0 to the eventual champions New York City FC in the opening round, while KC were upset 2-1 by Real Salt Lake in the Western Conference Semi-Finals.
We say: Atlanta United 2-3 Sporting Kansas City
Both of these teams are very aggressive, and they possess some deadly strikers who rarely miss their scoring opportunities, meaning that the defences could be in for a long afternoon this weekend.
LA Galaxy vs. NY City (Sunday, 10.00pm)
LA missed the playoffs for a second successive campaign in 2021, only losing out because they had fewer wins than Real Salt Lake, while The Pigeons won it all, beating the Portland Timbers in a penalty shootout.
We say: Los Angeles Galaxy 1-3 New York City FC
The Galaxy should score plenty of goals throughout this season, but we are leaning towards New York in this one as they have played in their share of competitive fixtures heading into this MLS opener.