Paris Saint-Germain striker Edinson Cavani has failed to make Uruguay's starting XI for their World Cup quarter-final against France due to injury concerns.
The influential forward will start on the bench for the knockout tie, with former Middlesbrough attacker Cristhian Stuani partnering Luis Suarez up front in his absence.
Oscar Tabarez has otherwise named an unchanged side from the 2-1 victory over Spain in the last 16, with Jose Gimenez keeping his place in defence, having fully recovered from a back problem.
France, meanwhile, have made only one change from the side which saw off Argentina 4-3 in the last 16.
Corentin Tolisso has been drafted into Les Bleus' midfield to replace the suspended Blaise Matuidi.
Uruguay: Muslera; Gimenez, Godin, Caceres, Laxalt; Nandez, Torreira, Bentancur, Vecino; Suarez, Stuani
Subs: Varela, Sanchez, Rodriguez, De Arrascaeta, Campana, Silva, Pereira, Gomez, Coates, Urretaviscaya, Cavani, M. Silva
France: Lloris; Hernandez, Umtiti, Varane, Pavard; Kante, Pogba; Tolisso, Griezmann, Mbappe; Giroud
Subs: Kimpembe, Lemar, Dembele, N'Zonzi, Mandanda, Rami, Fekir, Sidibe, Thauvin, Mendy, Areola
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