Pat Noonan's side played out an enthralling 4-4 draw with Inter Miami last time out, while the visitors humiliated the Houston Dynamo 6-0.
A lack of ruthlessness is not the issue for Cincinnati, but shutting up shop in their defensive third is proving to be a significant challenge for Noonan, whose side have now gone seven games without victory in MLS.
In what was described by the Cincinnati boss as a "chaotic" encounter, Brenner and Brandon Vazquez both hit braces against Inter Miami, but Gonzalo Higuain rolled back the years with a hat-trick before an unlikely hero in Christopher McVey hit the final equaliser for Phil Neville's side in the seventh minute of second-half injury time.
Incredibly, that represented Cincinnati's second 4-4 draw in the space of a month - Noonan's side also shared eight goals around with New York City at the end of June - and it is now six draws in seven for this weekend's hosts.
Cincinnati are clinging onto the seventh and final playoff spot in the Eastern Conference, despite conceding the second-most goals in their section with 42 - only basement side DC United (44) have a worse record in that regard.
As many as four sides are capable of usurping Cincinnati should results not go Noonan's way this weekend, but not since March have the Orange and Blue failed to score in front of their own supporters, and each of their last four at the TQL Stadium has ended level.
Goal-laden performances have also been on the menu for Jim Curtin and the Philadelphia Union in recent weeks, but unlike their leaky hosts, the Eastern Conference leaders tend to only make the net ripple at the other end of the pitch.
Six goals from five different scorers got the job done in emphatic fashion against the Houston Dynamo last weekend, as Mikael Uhre netted a brace alongside Daniel Gazdag, Julian Carranza, Jack McGlynn and Quinn Sullivan.
A fifth successive victory leaves the Union sitting pretty at the top of the Eastern Conference - three points clear of New York City having played a game more - but Los Angeles FC are still leading the race for the Supporters' Shield.
Curtin's prolific crop have struck 18 goals and conceded a mere two during their five-game winning run, but a paltry record of three victories from their last 10 away from home will give Cincinnati some hope that an upset could be on the cards.
Cincinnati managed to hold the Union to a 1-1 draw as recently as last month, but the hosts are still waiting for their first victory in this fixture and have only ever breached the Union's defence twice in seven matches.
Sergio Santos will also need assessing as he battles back from a leg issue, while captain and creative hub Luciano Acosta reportedly came off with a physical problem of his own in the dying embers of the 4-4 draw with Inter Miami.
Meanwhile, Philadelphia Union's remarkable form has coincided with an empty treatment room, as Curtin is set to be working with a fully-fit squad once more.
Sullivan's goal off the bench may give Curtin some food for thought, but the visiting coach will be loath to make any changes to his first XI for Saturday's game.
FC Cincinnati possible starting lineup:
Celentano; Hagglund, Murphy, Blackett; Powell, Moreno, Acosta, Nwobodo, Barreal; Vazquez, Brenner
Philadelphia Union possible starting lineup:
Blake; Mbaizo, Glesnes, Elliott, Wagner; McGlynn, Flach, Bedoya; Gazdag; Uhre, Carranza
We say: FC Cincinnati 1-3 Philadelphia Union
Cincinnati fans are sick of the sight of stalemates now, but most would most likely accept a draw versus the Eastern Conference leaders, whose penchant for goals should become apparent here.
Carving their way through a leaky Orange and Blue backline should be an easy ask for the Union, who also have the defensive nous to end the hosts' unbeaten run at the TQL Stadium.
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