Liverpool could move top of the Premier League table for 24 hours at least when they face off against bitter rivals Manchester United in Tuesday's headline fixture.
Elsewhere, Fulham could seal promotion to the Premier League, there is a Milan derby in the Coppa Italia and La Liga also hosts a midweek round of matches.
Below is Sports Mole's selection of predictions and previews for today's and tomorrow's fixtures.
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| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Manchester CityMan City | 31 | 23 | 5 | 3 | 72 | 20 | 52 | 74 |
| 2 | Liverpool | 31 | 22 | 7 | 2 | 79 | 22 | 57 | 73 |
| 3 | Chelsea | 30 | 18 | 8 | 4 | 64 | 23 | 41 | 62 |
| 4 | Tottenham HotspurSpurs | 32 | 18 | 3 | 11 | 56 | 38 | 18 | 57 |
| 5 | Manchester UnitedMan Utd | 32 | 15 | 9 | 8 | 52 | 44 | 8 | 54 |
| 6 | Arsenal | 31 | 17 | 3 | 11 | 45 | 37 | 8 | 54 |
| 7 | West Ham UnitedWest Ham | 33 | 15 | 7 | 11 | 52 | 43 | 9 | 52 |
| 8 | Wolverhampton WanderersWolves | 32 | 15 | 4 | 13 | 33 | 28 | 5 | 49 |
| 9 | Leicester CityLeicester | 30 | 11 | 7 | 12 | 46 | 50 | -4 | 40 |
| 10 | Brighton & Hove AlbionBrighton | 32 | 9 | 13 | 10 | 29 | 37 | -8 | 40 |
| 11 | Brentford | 33 | 11 | 6 | 16 | 41 | 49 | -8 | 39 |
| 12 | Southampton | 32 | 9 | 12 | 11 | 38 | 52 | -14 | 39 |
| 13 | Crystal Palace | 31 | 8 | 13 | 10 | 43 | 40 | 3 | 37 |
| 14 | Newcastle UnitedNewcastle | 32 | 9 | 10 | 13 | 36 | 55 | -19 | 37 |
| 15 | Aston Villa | 31 | 11 | 3 | 17 | 42 | 46 | -4 | 36 |
| 16 | Leeds UnitedLeeds | 32 | 8 | 9 | 15 | 38 | 68 | -30 | 33 |
| 17 | Everton | 30 | 8 | 4 | 18 | 33 | 52 | -19 | 28 |
| 18 | Burnley | 31 | 4 | 13 | 14 | 26 | 45 | -19 | 25 |
| 19 | Watford | 32 | 6 | 4 | 22 | 30 | 62 | -32 | 22 |
| 20 | Norwich CityNorwich | 32 | 5 | 6 | 21 | 22 | 66 | -44 | 21 |
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Manchester CityMan City | 31 | 23 | 5 | 3 | 72 | 20 | 52 | 74 |
| 2 | Liverpool | 31 | 22 | 7 | 2 | 79 | 22 | 57 | 73 |
| 3 | Chelsea | 30 | 18 | 8 | 4 | 64 | 23 | 41 | 62 |
| 4 | Tottenham HotspurSpurs | 32 | 18 | 3 | 11 | 56 | 38 | 18 | 57 |
| 5 | Manchester UnitedMan Utd | 32 | 15 | 9 | 8 | 52 | 44 | 8 | 54 |
| 6 | Arsenal | 31 | 17 | 3 | 11 | 45 | 37 | 8 | 54 |
| 7 | West Ham UnitedWest Ham | 33 | 15 | 7 | 11 | 52 | 43 | 9 | 52 |
| 8 | Wolverhampton WanderersWolves | 32 | 15 | 4 | 13 | 33 | 28 | 5 | 49 |
| 9 | Leicester CityLeicester | 30 | 11 | 7 | 12 | 46 | 50 | -4 | 40 |
| 10 | Brighton & Hove AlbionBrighton | 32 | 9 | 13 | 10 | 29 | 37 | -8 | 40 |
| 11 | Brentford | 33 | 11 | 6 | 16 | 41 | 49 | -8 | 39 |
| 12 | Southampton | 32 | 9 | 12 | 11 | 38 | 52 | -14 | 39 |
| 13 | Crystal Palace | 31 | 8 | 13 | 10 | 43 | 40 | 3 | 37 |
| 14 | Newcastle UnitedNewcastle | 32 | 9 | 10 | 13 | 36 | 55 | -19 | 37 |
| 15 | Aston Villa | 31 | 11 | 3 | 17 | 42 | 46 | -4 | 36 |
| 16 | Leeds UnitedLeeds | 32 | 8 | 9 | 15 | 38 | 68 | -30 | 33 |
| 17 | Everton | 30 | 8 | 4 | 18 | 33 | 52 | -19 | 28 |
| 18 | Burnley | 31 | 4 | 13 | 14 | 26 | 45 | -19 | 25 |
| 19 | Watford | 32 | 6 | 4 | 22 | 30 | 62 | -32 | 22 |
| 20 | Norwich CityNorwich | 32 | 5 | 6 | 21 | 22 | 66 | -44 | 21 |
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