Manchester United will again be missing some key players when they head to Spain on Tuesday night to face Villarreal in the Champions League.
Michael Carrick will pick the team following Ole Gunnar Solskjaer's dismissal, and it is likely that the stand-in head coach will make a number of changes from the 4-1 defeat to Watford on Saturday.
Luke Shaw is a major doubt, having come off with another suspected concussion at Vicarage Road, and Diogo Dalot could hold off competition from Alex Telles to earn a start.
Eric Bailly could also feature against his former club, as the Ivory Coast international is expected to be in the first XI against Chelsea next weekend due to Harry Maguire's suspension.
Donny van de Beek and Fred could start in a new-look midfield, with Scott McTominay and Nemanja Matic dropping out, but Jadon Sancho, Bruno Fernandes and Marcus Rashford may again be selected in support of Cristiano Ronaldo.
Paul Pogba and Raphael Varane will definitely miss out through injury, while Edinson Cavani is unlikely to be involved, with the striker battling a tendon problem.
Jesse Lingard is also pushing to be involved in the first XI, but it is unlikely that Carrick will make the decision to drop Fernandes for the key Champions League encounter.
Mason Greenwood will also be absent for the visitors, having tested positive for coronavirus.
Manchester United possible starting lineup: De Gea; Wan-Bissaka, Bailly, Maguire, Dalot; Van de Beek, Fred; Sancho, Fernandes, Rashford; Ronaldo