Manchester United host Arsenal in the pick of Thursday's fixtures, but new interim boss Ralf Rangnick will not be in the dugout due to work permit issues.
Tottenham Hotspur are also in action against Burnley, while Celtic, Ajax and Lazio are among the other big names to feature around Europe.
Below is Sports Mole's selection of predictions and previews for all of today's and tomorrow's fixtures.
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| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Chelsea | 14 | 10 | 3 | 1 | 33 | 6 | 27 | 33 |
| 2 | Manchester CityMan City | 14 | 10 | 2 | 2 | 29 | 8 | 21 | 32 |
| 3 | Liverpool | 14 | 9 | 4 | 1 | 43 | 12 | 31 | 31 |
| 4 | West Ham UnitedWest Ham | 14 | 7 | 3 | 4 | 25 | 17 | 8 | 24 |
| 5 | Arsenal | 13 | 7 | 2 | 4 | 15 | 17 | -2 | 23 |
| 6 | Wolverhampton WanderersWolves | 14 | 6 | 3 | 5 | 12 | 12 | 0 | 21 |
| 7 | Brighton & Hove AlbionBrighton | 14 | 4 | 7 | 3 | 13 | 15 | -2 | 19 |
| 8 | Leicester CityLeicester | 14 | 5 | 4 | 5 | 22 | 25 | -3 | 19 |
| 9 | Tottenham HotspurSpurs | 12 | 6 | 1 | 5 | 11 | 17 | -6 | 19 |
| 10 | Manchester UnitedMan Utd | 13 | 5 | 3 | 5 | 21 | 22 | -1 | 18 |
| 11 | Brentford | 13 | 4 | 4 | 5 | 17 | 17 | 0 | 16 |
| 12 | Crystal Palace | 14 | 3 | 7 | 4 | 19 | 20 | -1 | 16 |
| 13 | Aston Villa | 14 | 5 | 1 | 8 | 19 | 23 | -4 | 16 |
| 14 | Everton | 14 | 4 | 3 | 7 | 17 | 24 | -7 | 15 |
| 15 | Leeds UnitedLeeds | 14 | 3 | 6 | 5 | 13 | 20 | -7 | 15 |
| 16 | Southampton | 14 | 3 | 6 | 5 | 13 | 20 | -7 | 15 |
| 17 | Watford | 14 | 4 | 1 | 9 | 19 | 26 | -7 | 13 |
| 18 | Burnley | 13 | 1 | 7 | 5 | 14 | 20 | -6 | 10 |
| 19 | Norwich CityNorwich | 14 | 2 | 4 | 8 | 8 | 28 | -20 | 10 |
| 20 | Newcastle UnitedNewcastle | 14 | 0 | 7 | 7 | 16 | 30 | -14 | 7 |
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Chelsea | 14 | 10 | 3 | 1 | 33 | 6 | 27 | 33 |
| 2 | Manchester CityMan City | 14 | 10 | 2 | 2 | 29 | 8 | 21 | 32 |
| 3 | Liverpool | 14 | 9 | 4 | 1 | 43 | 12 | 31 | 31 |
| 4 | West Ham UnitedWest Ham | 14 | 7 | 3 | 4 | 25 | 17 | 8 | 24 |
| 5 | Arsenal | 13 | 7 | 2 | 4 | 15 | 17 | -2 | 23 |
| 6 | Wolverhampton WanderersWolves | 14 | 6 | 3 | 5 | 12 | 12 | 0 | 21 |
| 7 | Brighton & Hove AlbionBrighton | 14 | 4 | 7 | 3 | 13 | 15 | -2 | 19 |
| 8 | Leicester CityLeicester | 14 | 5 | 4 | 5 | 22 | 25 | -3 | 19 |
| 9 | Tottenham HotspurSpurs | 12 | 6 | 1 | 5 | 11 | 17 | -6 | 19 |
| 10 | Manchester UnitedMan Utd | 13 | 5 | 3 | 5 | 21 | 22 | -1 | 18 |
| 11 | Brentford | 13 | 4 | 4 | 5 | 17 | 17 | 0 | 16 |
| 12 | Crystal Palace | 14 | 3 | 7 | 4 | 19 | 20 | -1 | 16 |
| 13 | Aston Villa | 14 | 5 | 1 | 8 | 19 | 23 | -4 | 16 |
| 14 | Everton | 14 | 4 | 3 | 7 | 17 | 24 | -7 | 15 |
| 15 | Leeds UnitedLeeds | 14 | 3 | 6 | 5 | 13 | 20 | -7 | 15 |
| 16 | Southampton | 14 | 3 | 6 | 5 | 13 | 20 | -7 | 15 |
| 17 | Watford | 14 | 4 | 1 | 9 | 19 | 26 | -7 | 13 |
| 18 | Burnley | 13 | 1 | 7 | 5 | 14 | 20 | -6 | 10 |
| 19 | Norwich CityNorwich | 14 | 2 | 4 | 8 | 8 | 28 | -20 | 10 |
| 20 | Newcastle UnitedNewcastle | 14 | 0 | 7 | 7 | 16 | 30 | -14 | 7 |
