Manchester United welcome West Ham to Old Trafford on Saturday, while runaway leaders Manchester City are also among those in Premier League action.
In the Championship there is the Severnside derby between Bristol City and Cardiff City, while Atletico Madrid, Inter Milan and Borussia Dortmund are among the other big clubs to feature.
Below is Sports Mole's selection of predictions and previews for today's and tomorrow's fixtures.
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| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Manchester CityMan City | 23 | 18 | 3 | 2 | 55 | 14 | 41 | 57 |
| 2 | Liverpool | 21 | 13 | 6 | 2 | 55 | 18 | 37 | 45 |
| 3 | Chelsea | 23 | 12 | 8 | 3 | 46 | 18 | 28 | 44 |
| 4 | Manchester UnitedMan Utd | 22 | 11 | 5 | 6 | 36 | 30 | 6 | 38 |
| 5 | West Ham UnitedWest Ham | 23 | 11 | 4 | 8 | 41 | 31 | 10 | 37 |
| 6 | Tottenham HotspurSpurs | 19 | 11 | 3 | 5 | 26 | 22 | 4 | 36 |
| 7 | Arsenal | 20 | 11 | 2 | 7 | 33 | 25 | 8 | 35 |
| 8 | Wolverhampton WanderersWolves | 21 | 10 | 4 | 7 | 19 | 16 | 3 | 34 |
| 9 | Brighton & Hove AlbionBrighton | 21 | 6 | 11 | 4 | 22 | 22 | 0 | 29 |
| 10 | Aston Villa | 21 | 8 | 2 | 11 | 28 | 32 | -4 | 26 |
| 11 | Leicester CityLeicester | 19 | 7 | 4 | 8 | 33 | 36 | -3 | 25 |
| 12 | Southampton | 22 | 5 | 10 | 7 | 26 | 34 | -8 | 25 |
| 13 | Crystal Palace | 21 | 5 | 9 | 7 | 30 | 31 | -1 | 24 |
| 14 | Brentford | 23 | 6 | 5 | 12 | 26 | 38 | -12 | 23 |
| 15 | Leeds UnitedLeeds | 21 | 5 | 7 | 9 | 24 | 40 | -16 | 22 |
| 16 | Everton | 20 | 5 | 4 | 11 | 24 | 35 | -11 | 19 |
| 17 | Norwich CityNorwich | 22 | 4 | 4 | 14 | 13 | 45 | -32 | 16 |
| 18 | Newcastle UnitedNewcastle | 21 | 2 | 9 | 10 | 21 | 43 | -22 | 15 |
| 19 | Watford | 20 | 4 | 2 | 14 | 23 | 40 | -17 | 14 |
| 20 | Burnley | 17 | 1 | 8 | 8 | 16 | 27 | -11 | 11 |
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Manchester CityMan City | 23 | 18 | 3 | 2 | 55 | 14 | 41 | 57 |
| 2 | Liverpool | 21 | 13 | 6 | 2 | 55 | 18 | 37 | 45 |
| 3 | Chelsea | 23 | 12 | 8 | 3 | 46 | 18 | 28 | 44 |
| 4 | Manchester UnitedMan Utd | 22 | 11 | 5 | 6 | 36 | 30 | 6 | 38 |
| 5 | West Ham UnitedWest Ham | 23 | 11 | 4 | 8 | 41 | 31 | 10 | 37 |
| 6 | Tottenham HotspurSpurs | 19 | 11 | 3 | 5 | 26 | 22 | 4 | 36 |
| 7 | Arsenal | 20 | 11 | 2 | 7 | 33 | 25 | 8 | 35 |
| 8 | Wolverhampton WanderersWolves | 21 | 10 | 4 | 7 | 19 | 16 | 3 | 34 |
| 9 | Brighton & Hove AlbionBrighton | 21 | 6 | 11 | 4 | 22 | 22 | 0 | 29 |
| 10 | Aston Villa | 21 | 8 | 2 | 11 | 28 | 32 | -4 | 26 |
| 11 | Leicester CityLeicester | 19 | 7 | 4 | 8 | 33 | 36 | -3 | 25 |
| 12 | Southampton | 22 | 5 | 10 | 7 | 26 | 34 | -8 | 25 |
| 13 | Crystal Palace | 21 | 5 | 9 | 7 | 30 | 31 | -1 | 24 |
| 14 | Brentford | 23 | 6 | 5 | 12 | 26 | 38 | -12 | 23 |
| 15 | Leeds UnitedLeeds | 21 | 5 | 7 | 9 | 24 | 40 | -16 | 22 |
| 16 | Everton | 20 | 5 | 4 | 11 | 24 | 35 | -11 | 19 |
| 17 | Norwich CityNorwich | 22 | 4 | 4 | 14 | 13 | 45 | -32 | 16 |
| 18 | Newcastle UnitedNewcastle | 21 | 2 | 9 | 10 | 21 | 43 | -22 | 15 |
| 19 | Watford | 20 | 4 | 2 | 14 | 23 | 40 | -17 | 14 |
| 20 | Burnley | 17 | 1 | 8 | 8 | 16 | 27 | -11 | 11 |
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