Billy Horschel and Scott Piercy have put together a final-round 67 to secure victory at the Zurich Classic of New Orleans event.
The American duo began Sunday's play three shots off the pace but five birdies in a faultless round resulted in Jason Dufner and Pat Perez being edged out by one shot.
South African pairing Charl Schwartzel and Louis Oosthuizen finished in third position, while an eagle on the last saw Tommy Fleetwood and Chris Paisley take a share of fourth alongside Brice Garnett and Chesson Hadley.
Masters champion Patrick Reed and Patrick Cantlay ended the tournament in seventh spot, but Justin Rose and Henrik Stenson only finished in 19th place after a last-round 73.
The British pairing of Graeme McDowell and Ian Poulter could only finish in 22nd after also posting a 73 on Sunday.
ZURICH CLASSIC OF NEW ORLEANS
1. Billy Horschel/Scott Piercy (-22)
2. Jason Dufner/Pat Perez (-21)
3. Charl Schwartzel/Louis Oosthuizen (-20)
4. Tommy Fleetwood/Chris Paisley (-19)
= Brice Garnett/Chesson Hadley (-19)