With a place in the knockout stages up for grabs, Wales and England go head to head at the Ahmed bin Ali Stadium in the final round of Group B matches on Tuesday.
Following a 64-year absence from the World Cup, Wales' return to the global showpiece has been far from impressive as they face the risk of early elimination after picking up one point from their opening two matches.
Robert Page's men fought back from behind to snatch a 1-1 draw against USA in their group opener on November 21, but were left stunned by Iran, who claimed a 2-0 victory when the sides squared off last Friday.
After being under the cosh for most of the game, the Dragons finally succumbed to pressure from the Iranians as Roozbeh Cheshmi and Ramin Razaeian netted stoppage-time goals after Wayne Hennessey had received a red card for a dangerous tackle on Porto striker Mehdi Taremi.
England, who opened their campaign with a 6-2 victory over Iran, head into Tuesday needing at least a draw to secure a second consecutive knockout-stage appearance as they currently lead the way in Group B with four points from a possible six.
Off the back of a goalless draw against USA in their second round of group fixtures, Gareth Southgate will hope for a much better performance from his side, who appeared to receive boos from some of the England contingent after being outplayed by the Stars and Stripes.
However, the Three Lions will fancy their chances of getting the job done and even coming out victorious in another highly-anticipated battle of the Brits as they boast an excellent run of results over Wales.
England are unbeaten in 89 of their last 103 matches against Wales, claiming 21 draws and a staggering 68 wins, including a 2-1 victory in the first encounter between the sides in January 1879.
Bottom of the Group B standings and needing a win to keep their slender hopes alive, Wales must end a run of six consecutive defeats against England and secure what will be just their 15th win in the history of this fixture.
Their most recent victory over the Three Lions came in the British Home Championship back in May 1984, when Mark Hughes struck in the 17th minute to sink Southgate's side at the Racecourse Ground.
However, Page's side head into Tuesday without a World Cup-related victory against England, losing all but one of their previous six encounters while holding out for a 1-1 draw in Group 5 back in 1973.
Wales are also yet to defeat the Three Lions in any major tournament after losing each of the five UEFA European Championship qualification meetings between the sides since November 1966.
WALES VS. ENGLAND HEAD-TO-HEAD RECORD
Wales wins: 14
England wins: 68
Draws: 21
Wales goals: 91
England goals: 250
MATCH HISTORY
January 18, 1879: Wales 1-2 England (International Friendly)
March 15, 1880: Wales 3-1 England International Friendly
February, 26 1881: Wales 1-0 England (International Friendly)
March 13, 1882: Wales 5-3 England (International Friendly)
February 3, 1883: Wales 0-5 England (International Friendly)
March 17, 1884: Wales 0-4 England (British Home Championship)
March 14, 1885: Wales 1-1 England (British Home Championship)
March 29, 1886: Wales 1-3 England (British Home Championship)
February 26, 1887: Wales 0-4 England (British Home Championship)
February 4, 1888: Wales 1-5 England (British Home Championship)
February 23, 1889: Wales 1-4 England (British Home Championship)
March 15, 1890: Wales 1-3 England (British Home Championship)
March 7, 1891: Wales 1-4 England (British Home Championship)
March 5, 1892: Wales 0-2 England (British Home Championship)
March 13, 1893: Wales 6-0 Wales (British Home Championship)
March 12, 1894: Wales 1-5 England (British Home Championship)
March 18, 1895: Wales 1-1 England (British Home Championship)
March 16, 1896: Wales 1-9 England (British Home Championship)
March 29, 1897: Wales 0-4 England (British Home Championship)
March 28, 1898: Wales 0-3 England (British Home Championship)
March 20, 1899: Wales 0-4 England (British Home Championship)
March 26, 1900: Wales 1-1 England (British Home Championship)
March 18 1901: Wales 0-6 England (British Home Championship)
March 3, 1902: Wales 0-0 England (British Home Championship)
March 2, 1903: Wales 1-2 England (British Home Championship)
February 29, 1904: Wales 2-2 England (British Home Championship)
March 27, 1905: Wales 1-3 England (British Home Championship)
March 19, 1906: Wales 0-1 England (British Home Championship)
March 18, 1907: Wales 1-1 England (British Home Championship)
March 16, 1908: Wales 1-7 England (British Home Championship)
March 15, 1909: Wales 0-2 England (British Home Championship)
March 14, 1910: Wales 0-1 England (British Home Championship)
March 13, 1911: Wales 0-3 England (British Home Championship)
March 11, 1912: Wales 0-2 England (British Home Championship)
March 17, 1913: Wales 3-4 England (British Home Championship)
March 16, 1914: Wales 0-2 England (British Home Championship)
March 15, 1920: Wales 2-1 England (British Home Championship)
March 14, 1921: Wales 0-0 England (British Home Championship)
March 13, 1922: Wales 0-1 England (British Home Championship)
March 5, 1923: Wales 2-2 England (British Home Championship)
March 3, 1924: Wales 2-1 England (British Home Championship)
February 28, 1925: Wales 1-2 England (British Home Championship)
March 1, 1926: Wales 1-3 England (British Home Championship)
February 12, 1927: Wales 3-3 England (British Home Championship)
November 28, 1927: Wales 2-1 England (British Home Championship)
November 17, 1928: Wales 2-3 England (British Home Championship)
November 20, 1929: Wales 0-6 England (British Home Championship)
November 22, 1930: Wales 0-4 England (British Home Championship)
November 18, 1931: Wales 1-3 England (British Home Championship)
November 16, 1932: Wales 0-0 England (British Home Championship)
November 15, 1933: Wales 2-1 England (British Home Championship)
September 29, 1934: Wales 0-4 England (British Home Championship)
February 5, 1936: Wales 2-1 England (British Home Championship)
October 17, 1936: Wales 2-1 England (British Home Championship)
November 17, 1937: Wales 2-1 England (British Home Championship)
October 22, 1938: Wales 4-2 England (British Home Championship)
November 13, 1946: Wales 0-3 England (British Home Championship)
October 18, 1947: Wales 0-3 England (British Home Championship)
November 10, 1948: Wales 0-1 England (British Home Championship)
October 15, 1949: Wales 1-4 England (FIFA World Cup)
November 15, 1950: Wales 2-4 England (British Home Championship)
October 20, 1951: Wales 1-1 England (British Home Championship)
November 12, 1952: Wales 2-5 England (British Home Championship)
October 10, 1953: Wales 1-4 England (FIFA World Cup)
November 10, 1954: Wales 2-3 England (British Home Championship)
October 22, 1955: Wales 2-1 England (British Home Championship)
November 14, 1956: Wales 1-3 England (British Home Championship)
October 19, 1957: Wales 0-4 England (British Home Championship)
November 26, 1958: Wales 2-2 England (British Home Championship)
October 17, 1959: Wales 1-1 England (British Home Championship)
November 23, 1960: Wales 5-1 England (British Home Championship)
October 14, 1961: Wales 1-1 England (British Home Championship)
November 21, 1962: Wales 0-4 England (British Home Championship)
October 12, 1963: Wales 0-4 England (British Home Championship)
November 18, 1964: Wales 1-2 England (British Home Championship)
October 2, 1965: Wales 0-0 England (British Home Championship)
November 16, 1966: Wales 1-5 England (UEFA European Championship qualifying)
October 21, 1967: Wales 0-3 England (UEFA European Championship qualifying)
May 7, 1969: Wales 1-2 England (British Home Championship)
April 18, 1970: Wales 1-1 England (British Home Championship)
May 19, 1971: Wales 0-0 England (British Home Championship)
May 20, 1972: Wales 0-3 England (British Home Championship)
November 15, 1972: Wales 0-1 England (FIFA World Cup qualifying)
January 24, 1973: Wales 1-1 England (FIFA World Cup qualifying)
May 15, 1973: Wales 0-3 England (British Home Championship)
May 11, 1974: Wales 0-2 England (British Home Championship)
May 21, 1975: Wales 2-2 England (British Home Championship)
March 24, 1976: Wales 1-2 England (Centenary Match)
May 8, 1976: Wales 0-1 England (British Home Championship)
May 31, 1977: Wales 1-0 England (British Home Championship)
May 13, 1978: Wales 1-3 England (British Home Championship)
May 23, 1979: Wales 0-0 England (British Home Championship)
May 17, 1980: Wales 4-1 England (British Home Championship)
May 20, 1981: Wales 0-0 England (British Home Championship)
April 27, 1982: Wales 0-1 England (British Home Championship)
February 23, 1983: Wales 1-2 England (British Home Championship)
May 2, 1984: Wales 1-0 England (British Home Championship)
October 9, 2004: Wales 0-2 England (FIFA World Cup qualifying)
September 3, 2005: Wales 0-1 England (FIFA World Cup qualifying)
March 26, 2011: Wales 0-2 England (UEFA European Championship qualifying)
September 6, 2011: Wales 0-1 England (UEFA European Championship qualifying)
June 16, 2016: Wales 1-2 England (UEFA European Championship)
October 8, 2020: Wales 0-3 England (International Friendly)
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