Forward Son Heung-min will certainly miss out through injury, with the South Korean star set to be absent for the remainder of the month.
Left-back Sergio Reguilon is another player likely to miss out alongside Steven Bergwijn, and Ryan Sessegnon could be tasked with operating on the left-hand side in his absence with Emerson Royal featuring on the opposite wing.
Midfielder Tanguy Ndombele has seemingly fallen out of favour with the Italian manager, and the Frenchman may have to endure a spell on the bench, with Pierre-Emile Hojbjerg bring the most likely man to feature in the centre for the Lilywhites.
The likes of Harry Winks, Oliver Skipp, Dele Alli and Giovani Lo Celso will be forced to battle for their spots around the Dane, whether Conte deploys a midfield three or a duo with additional support for Kane and Moura.
Tottenham Hotspur possible starting lineup: Lloris; Tanganga, Sanchez, Davies; Royal, Winks, Hojbjerg, Sessegnon; Alli, Kane, Moura body check tags ::