Arsenal vs. Brighton (Sunday, 2.00pm)
Facing the team who subjected them to their most recent Premier League home defeat, Arsenal welcome Brighton & Hove Albion to their Emirates base on Sunday afternoon.
A win for the Gunners would enable them to return to the top of the rankings - for a couple of hours at least - while the Seagulls head to North London on the back of another momentous European occasion.
We say: Arsenal 3-1 Brighton & Hove Albion
Brighton may have had their way with Arsenal at the Emirates in recent times, but defensive stability has evaded them since their last Emirates stopover, and a lack of recuperation time will no doubt harm De Zerbi's troops too.
The Seagulls boss can still call upon several competent options for change, but with Arteta also reverting to a full-strength team at their newly-fortified base, we expect the Gunners to bring the Seagulls crashing down to earth.
> Click here to read our full preview for this match
> How Arsenal could line up against Brighton
> Arsenal injury, suspension list vs. Brighton
Brentford vs. Aston Villa (Sunday, 2.00pm)
Fresh from winning their Europa Conference League group, Aston Villa are back in Premier League action on Sunday, when Brentford welcome Unai Emery's team to the Gtech Community Stadium.
The Lions progressed in Europe thanks to a 1-1 draw away to Zrinjski Mostar in midweek, while the Bees have a few wrongs to right after losing 1-0 to Sheffield United last weekend.
We say: Brentford 1-2 Aston Villa
Brentford would do well to capitalise on Villa's fatigued legs and double suspension blow, but Emery has well-rested options for change all over the shop, including an Ollie Watkins desperate to show his former club what they are missing.
The Lions' powers often wane away from their Villa Park base, but with Brentford hit with significant attacking and defensive absences, we have faith in Emery's rejigged side to prevail by the narrowest of margins.
> Click here to read our full preview for this match
West Ham vs. Wolves (Sunday, 2.00pm)
On the back of sealing progression to the last 16 of the Europa League, West Ham United take to the London Stadium turf again on Sunday, as Wolverhampton Wanderers arrive for a Premier League date.
David Moyes's side advanced on the continent thanks to a 2-0 beating of Freiburg on Thursday, while their visitors came from behind to hold Nottingham Forest to a 1-1 draw last weekend.
We say: West Ham United 1-1 Wolverhampton Wanderers
Wolves are guilty of leaving the back door open away from home, but O'Neil's men often make at least one of their attacking forays count for something on rival territory and can feel confident of ending their painful scoreless run at the London Stadium.
A solitary goal may even be enough for O'Neil's steadfast troops to depart with a point, as West Ham have fewer than 72 hours in between matches and may struggle to penetrate O'Neil's defensive setup more than once.
> Click here to read our full preview for this match
Liverpool vs. Man Utd (Sunday, 4.30pm)
Forced to relive painful memories of last season's seven-goal slaughter, Manchester United make a short trip to Merseyside to face Liverpool in front of what is anticipated to be a record-breaking Anfield crowd on Sunday.
As many as 57,000 fans are expected to saunter through the turnstiles to witness this weekend's headline Premier League contest, where the two titans are both aiming to rectify some midweek mistakes.
We say: Liverpool 3-0 Manchester United
Man United may benefit from an additional two days of recovery from their European exertions, but with the bulk of Liverpool's big names spared for their loss to Union SG, jellied legs should not come into play for the current league leaders.
A repeat of March's seven-goal disaster should not materialise for Ten Hag's troops, but with levels of confidence and playing personnel dangerously low, the stage is set for Liverpool to teach the Red Devils another footballing lesson.
> Click here to read our full preview for this match
> How Man United could line up against Liverpool
> How Liverpool could line up against Man United
> Liverpool injury, suspension list vs. Man United
