Luton vs. Chelsea (Wednesday, 7.15pm)
Having fallen at the final hurdle in one domestic cup competition already this season, Chelsea will aim to take a step towards another Wembley outing when they take on Luton Town in the fifth round of the FA Cup on Wednesday.
While the Blues suffered penalty shootout heartache to Liverpool in the EFL Cup final at the weekend, Luton's top-six Championship hopes were boosted with a narrow success over Derby County.
We say: Luton Town 0-2 Chelsea
Luton ought to beware a wounded Chelsea seeking to lay down a marker at Kenilworth Road, but not many teams have experienced much joy on the Hatters' turf since the turn of the year.
The Luton faithful's hopes of an FA Cup upset are not unfounded by any means, but Tuchel surely cannot fathom any more domestic disappointments just yet, so we still expect the Blues to return to winning ways and book their spot in the quarter-finals.
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> How Chelsea could line up against Luton
> Chelsea injury, suspension list vs. Luton
Southampton vs. West Ham (Wednesday, 7.30pm)
With a spot in the quarter-finals of the FA Cup on the line, Southampton and West Ham United prepare for battle in the fifth round on Wednesday evening.
The Saints head into the encounter on the back of a 2-0 Premier League win over Norwich City, while David Moyes's side overcame Wolverhampton Wanderers 1-0.
We say: Southampton 2-1 West Ham United
This has all the makings of a truly fascinating affair between a Southampton side enjoying their best run of the season and a Hammers side seeking to mark their rapid rise with a slice of domestic glory.
It would not be at all surprising to see this one decided in extra time or from spot kicks, but with the Saints proving increasingly resilient at home and West Ham struggling to keep the back door shut on the road, we can envisage Hasenhuttl's men advancing to the last eight.
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Liverpool vs. Norwich (Wednesday, 8.15pm)
Having already collected one piece of domestic silverware this season, Liverpool will endeavour to advance to the FA Cup quarter-finals when Norwich City pay a visit to Anfield on Wednesday evening.
The Reds won a record-breaking ninth EFL Cup crown on Sunday by defeating Chelsea in a tense penalty shootout, while the Canaries most recently went down 2-0 to Southampton.
We say: Liverpool 2-0 Norwich City
A weakened Liverpool side could have Norwich sensing the opportunity for an upset, but the levels of morale in both camps could hardly be more contrasting.
The Reds will be in no mood for complacency on Wednesday and have produced dominant performance after dominant performance against Norwich, so Klopp's men should keep the quadruple dream alive with a convincing success.
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