Chelsea vs. Plymouth (Saturday, 12.30pm)
Chelsea will seek a straightforward route into the fifth round of the FA Cup when they welcome Plymouth Argyle to Stamford Bridge for their fourth-round tie on Saturday lunchtime.
Thomas Tuchel's men taught Chesterfield a footballing lesson in their opening encounter of this season's tournament, while the visitors saw off Birmingham City in the third round.
We say: Chelsea 4-1 Plymouth Argyle
Argyle have made a bit of a habit of producing goal-laden performances on the road and may fancy their chances against a youthful and depleted Chelsea backline, but their own issues in the defensive third could cost them dear once more.
With the Premier League title slipping further and further away from them, Chelsea ought to go strong in their bid for a shot at domestic silverware, and a simple route into the fifth round should await Tuchel's men.
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> How Chelsea could line up against Plymouth Argyle
> Chelsea injury, suspension list vs. Plymouth
Kidderminster vs. West Ham (Saturday, 12.30pm)
Kidderminster Harriers will be flying the flag for non-league football on Saturday lunchtime when they welcome Premier League outfit West Ham United to the Aggborough Stadium for their fourth round tie in the FA Cup.
The lowest-ranked team left in the competition currently sit third in the National League North table, 112 places below the Hammers who occupy fifth in the top flight.
We say: Kidderminster Harriers 0-4 West Ham United
While many Kidderminster fans and football neutrals will be rooting for another FA Cup upset on Saturday, West Ham are understandably the strong favourites for this David vs. Goliath clash.
Even though Moyes is expected to rotate his starting lineup, the Hammers should have plenty of strength in depth to win comfortably and book their place in the fifth round.
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Crystal Palace vs. Hartlepool (Saturday, 3.00pm)
Hartlepool United will be aiming to make history when they visit Crystal Palace in the FA Cup fourth round on Saturday.
The League Two outfit have never reached round five, but have beaten higher-tier opposition in all three previous rounds this season.
We say: Crystal Palace 3-1 Hartlepool United
Hartlepool will be hopeful of causing another cup upset, but Palace named a strong side in the third round and should do so again in this game. We think the Eagles will have too much quality despite the visitors' best efforts.
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Huddersfield vs. Barnsley (Saturday, 3.00pm)
Yorkshire sides Huddersfield Town and Barnsley meet in one of two all-Championship affairs in the FA Cup fourth round on Saturday afternoon.
The Terriers have promotion hopes and are currently fifth in the second tier, while the Tykes are rock bottom and in severe relegation danger.
We say: Huddersfield Town 2-0 Barnsley
The FA Cup third round provided Barnsley with some respite from their league struggles, but they only just edged past a side two divisions below them. With a run of defeats following in the Championship, we expect them to lose again here and Huddersfield to continue their impressive unbeaten run.
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Peterborough vs. QPR (Saturday, 3.00pm)
Peterborough United and Queens Park Rangers take a break from Championship action on Saturday afternoon to try to earn a place in the FA Cup fifth round.
At a time when Posh are five matches without success in the second tier, QPR have prevailed in five of their last six outings to move into fourth position in the standings.
We say: Peterborough United 0-2 Queens Park Rangers
While both managers will naturally make alterations to their sides, we do not feel it will influence the final result. QPR's strength in depth is far greater than their hosts, and that should help them claim a relatively comfortable win.
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Southampton vs. Coventry (Saturday, 3.00pm)
Championship outfit Coventry City will travel to St Mary's for their FA Cup fourth-round clash against Premier League side Southampton on Saturday afternoon.
The Saints beat Swansea City 3-2 after extra time in the third round, while the Sky Blues secured a narrow 1-0 win at home against Derby County.
We say: Southampton 2-0 Coventry City
Coventry have lacked consistency in recent weeks, winning three, losing three and drawing one in their last seven matches, and it remains to be seen which side will turn up at St Mary's.
The visitors will need to be on top of their game if they are to cause an upset this weekend; however, Southampton should have enough quality in their side to secure a routine win on home soil.
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Everton vs. Brentford (Saturday, 3.00pm)
The Frank Lampard era begins now for Everton, whose first game under the tutelage of the Chelsea legend takes place on Saturday with the visit of Brentford in the fourth round of the FA Cup.
The Toffees needed extra time to get the better of Hull City in the third round, while Thomas Frank's side ran out convincing 4-1 winners over Port Vale.
We say: Everton 2-1 Brentford
Even without Alli or Van de Beek pulling the strings from midfield, the new manager bounce should be in full effect for Everton as Lampard seeks to endear himself to the Goodison Park faithful right away.
Brentford's worrying losing streak before the international break, a lengthy injury list and friction over Toney's comments could all contribute to their downfall here, and we expect the Toffees to avenge their league defeat to Frank's side by booking their spot in round five.
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Stoke vs. Wigan (Saturday, 3.00pm)
League One high-flyers Wigan Athletic travel to Championship outfit Stoke City in the FA Cup fourth round on Saturday afternoon.
The Latics have promotion ambitions and are currently second in the third tier, while the Potters' playoff hopes are hanging in the balance in the division above as they sit 12th.
We say: Stoke City 1-2 Wigan Athletic
This should be an intriguing game given Wigan's remarkable unbeaten run and Stoke's place as the higher-ranking side. Michael O'Neill may decide that his team need to focus on getting back into Championship playoff contention, which could allow the Latics to cause another cup upset.
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Man City vs. Fulham (Saturday, 3.00pm)
Manchester City mark their return to action following the international break with the visit of Championship side Fulham for the fourth round of the FA Cup on Saturday afternoon.
Pep Guardiola's men eased past Swindon Town 4-1 in the third round to make it this far, while their second-tier visitors saw off Bristol City by a goal to nil.
We say: Manchester City 3-1 Fulham
Fulham have a taste for goals, Carvalho's rapid rise is showing no signs of showing down, and Mitrovic continues to be unplayable. Those factors may lead to optimism within the Craven Cottage ranks that a famous result at the Etihad is calling.
Silva ought to put out the strongest side possible amid his side's Championship title charge, but a refreshed Man City outfit and their abundance of attacking talent should still prove too strong for the Cottagers' backline.
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> How Man City could line up against Fulham
> Man City injury, suspension list vs. Fulham
Wolves vs. Norwich (Saturday, 3.00pm)
Two Premier League teams will lock horns in the fourth round of the FA Cup on Saturday afternoon as Wolverhampton Wanderers welcome Norwich City to Molineux.
The hosts have won their last two home matches, scoring three goals in each, while the Canaries netted three times in their most recent away win at Watford.
We say: Wolverhampton Wanderers 1-0 Norwich City
A goalless draw was played out the last time that these two sides faced each other in the Premier League, and another low-scoring affair could be on the cards this weekend.
Both Wolves and Norwich have decent form under their belts, but the hosts will be the favourites to edge into the fifth round.
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Cambridge vs. Luton (Saturday, 5.30pm)
Cambridge United will be hoping to cause another FA Cup upset when they host Championship side Luton Town in the fourth round on Saturday afternoon.
The League One outfit made headlines in the third round as they won 1-0 away at top-flight Newcastle United.
We say: Cambridge United 2-1 Luton Town
On home turf, Cambridge will fancy their chances of pulling off another shock – particularly against a Luton side whose priority will now be the Championship playoff race. We think there is a high chance that this tie will go to extra time or even penalties, but we think that the Yellows will be victorious.
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Spurs vs. Brighton (Saturday, 8.00pm)
One of three all-Premier League ties in the fourth round of the FA Cup will take place in North London on Saturday night, when Tottenham Hotspur play host to Brighton & Hove Albion.
The only previous meeting between these two sides in the competition came in the third round back in January 2005, with strikes from Ledley King and Robbie Keane securing a 2-1 win for Spurs at White Hart Lane.
We say: Tottenham Hotspur 1-1 Brighton & Hove Albion (Tottenham Hotspur to win 2-1 after extra-time)
Brighton have proven to be a challenging opponent for many teams this campaign, losing only five of their 26 games across all competitions.
Spurs may be frustrated at times against the Seagulls, but they should have enough quality in the final third to breach the visitors' backline and edge through a closely-fought encounter after extra-time.
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