Galatasaray vs. Barcelona (Thursday, 5.45pm)
Having been held to a 0-0 draw in front of their own fans in the first leg of their last-16 tie, Barcelona will endeavour to advance to the Europa League quarter-finals when Galatasaray welcome them to Turkey for the second leg.
Xavi's side enter the contest having hit Osasuna for four without reply in La Liga, while Domenec Torrent's men ran out 2-1 winners against Besiktas.
We say: Galatasaray 1-2 Barcelona (Barcelona win 2-1 on aggregate)
Barcelona could be in for a rough ride against Galatasaray on the unforgiving Nef Stadium turf, with the hosts enjoying the new manager bounce under Torrent and possessing quite the difference-maker in Akturkoglu.
A distinct lack of ruthlessness bedevilled the Catalans in the first leg, but with Xavi able to call upon so many talented attacking options, La Blaugrana will expect to break down a beleaguered Galatasaray defence and advance to the last eight.
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> How Barcelona could line up against Galatasaray
> Barcelona injury, suspension list vs. Galatasaray
Red Star vs. Rangers (Thursday, 5.45pm)
With one foot already in the Europa League quarter-finals, Rangers will be looking to finish the job when they travel to the Stadion Rajko Mitic for the second leg of their last-16 tie against Red Star Belgrade on Thursday evening.
The Gers, who eased to a 3-0 victory in the first leg at Ibrox last week, are on course to reach the last eight in European competition for the first time in 14 years.
We say: Red Star Belgrade 1-3 Rangers (Rangers to win 6-1 on aggregate)
As daunting as the Stadion Rajko Mitic experience may be for Rangers, Van Bronckhorst and co will be full of confidence heading into the second leg and they should have no problems in breaking down Red Star's backline once again.
The hosts will fancy their chances of finding the net on Thursday, but the Gers seem too strong for their Serbian counterparts and should win comfortably on aggregate.
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Monaco vs. Braga (Thursday, 5.45pm)
Seeking to overturn a 2-0 first-leg deficit, Monaco welcome Braga to the Stade Louis II for the second leg of their Europa League last-16 tie on Thursday evening.
Both teams head into this fixture after suffering 1-0 league defeats, with Monaco losing away at Strasbourg, while Braga were beaten at home against Gil Vicente.
We say: Monaco 1-1 Braga (Braga to win 3-1 on aggregate)
Monaco have struggled for goals of late, scoring in only one of their last three games, and they were frustrated in last week's first leg. Another challenging affair could be on the cards for the hosts on Thursday.
Braga are expected to take a more cautious approach to the second leg and even if their French counterparts do breach their backline, they should have enough resilience in their side to hold on for victory on aggregate.
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B. Leverkusen vs. Atalanta (Thursday, 5.45pm)
Trailing by a goal following the first leg of their Europa League last 16 tie, Bayer Leverkusen welcome Atalanta BC to the BayArena on Thursday.
An entertaining encounter in Bergamo raises the prospect of another close contest for a place in the quarter-finals, with the hosts trailing 3-2 from last week.
We say: Bayer Leverkusen 1-1 Atalanta BC (Atalanta win 4-3 on aggregate)
Despite a goal-laden and expansive first leg, neither side managed to score at all upon their return to domestic duty at the weekend, and Leverkusen may find Wirtz's absence as disruptive as Zapata's has been for Atalanta.
The Bergamaschi may be more miss than hit of late, but they are generally a force to be reckoned with away from home, so they can hang on for a draw to squeeze through to the last eight at their hosts' expense.
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Frankfurt vs. Real Betis (Thursday, 8.00pm)
Seeking to overturn a 2-1 first-leg deficit, Real Betis will travel to the Waldstadion to face Eintracht Frankfurt for the second leg of their Europa League last-16 tie on Thursday night.
Both sides head into this fixture after winning in their domestic leagues last weekend, with Frankfurt coming from behind to win 2-1 at home to VfL Bochum, while Betis secured a slender 1-0 home victory against Athletic Bilbao.
We say: Eintracht Frankfurt 2-1 Real Betis (Eintracht Frankfurt to win 4-2 on aggregate)
A closely-fought contest between two evenly-matched sides is set to be played out in Germany, though Frankfurt have the upper hand with both experience at this stage of the knockout rounds and a one-goal aggregate lead.
While this last-16 tie could go the distance, we feel that the hosts will edge past their Spanish counterparts and win by the same scoreline as in the first leg.
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Lyon vs. Porto (Thursday, 8.00pm)
Porto will be looking to overturn a 1-0 first-leg deficit when they travel to the Parc Olympique Lyonnais to face Lyon for the second leg of their Europa League last-16 tie on Thursday night.
The hosts have won only three of their last nine games on home soil across all competitions, while the visitors are unbeaten in each of their last 10 matches on the road, winning nine in the process.
We say: Lyon 2-2 Porto (Lyon to win 3-2 on aggregate)
Although Lyon currently have a one-goal advantage, there is still plenty to play for and an entertaining contest could be on the cards on Thursday night.
The hosts have struggled on home soil in the last few weeks and they will find it challenging to keep a clean sheet against a fired-up Porto outfit. However, Bosz's men also possess quality in the final third and we can see them playing out at least a draw, which would be enough to edge them through to the quarter-finals on aggregate.
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West Ham vs. Sevilla (Thursday, 8.00pm)
West Ham United head into the second leg of their Europa League last-16 tie with Sevilla facing a 1-0 deficit on aggregate.
Ahead of Thursday's game at the London Stadium, the Hammers sit in sixth position in the Premier League, while Sevilla are second in La Liga.
We say: West Ham United 1-1 Sevilla
While Moyes has talked up the chances of West Ham scoring on Thursday, it may prove far easier said than done. In what we expect to be a tight game, Sevilla could edge through courtesy of earning a draw in London, possibly making things increasingly difficult for their opponents with a goal in the first half.
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