The Basque outfit are currently eighth in the La Liga table on 19 points, while Granada have collected just 11 points this season, which has left them down in 17th position in the division.
Athletic have won four, drawn seven and lost two of their 13 La Liga matches this season, which has seen them collect 19 points, which is enough for eighth position ahead of the next set of fixtures.
Marcelino's side have only lost one of their last seven in Spain's top flight, although that defeat came at home to Cadiz on November 5, and they are now four matches without a victory at this level.
Indeed, since beating Villarreal on October 23, the Basque outfit have drawn with Espanyol, Real Sociedad and Levante, in addition to suffering the surprise one-goal reverse at home to Cadiz.
Athletic finished 10th in Spain's top flight last term but claimed fifth as recent as 2015-16 and will believe that they are capable of challenging for a potential European spot this season.
The Lions will be looking to make it back-to-back La Liga wins over Granada, meanwhile, having recorded a 2-1 victory when the two sides last locked horns at San Mames back in March.
Granada will enter Friday's match off the back of a 4-1 home loss to Real Madrid last weekend, while they also suffered a 2-0 defeat at Espanyol before the international break.
There is no getting away from the fact that it has been a tough start to the season for Robert Moreno's side, with a total of 11 points from 13 matches leaving them in 17th position, level on points with 18th-placed Elche.
Granada have finished seventh and ninth in their last two seasons at this level, so it would be fair to say that a lot was expected of them this season, but their performances thus far have been largely disappointing.
The Red and Whites have won two of their last three league meetings with Athletic but have not been victorious away to the Basque outfit in Spain's top flight since September 2014.
Granada have actually performed better on their travels this season than on home soil, collecting six points from seven away fixtures and only five from six games in front of their own supporters.
Athletic will be missing Asier Villalibre, Daniel Vivian, Peru Nolaskoain and Yuri Berchiche on Friday night through injury, but the Basque outfit do not have any fresh fitness concerns from training this week.
The visitors will also be unable to call upon the services of Monchu, with the midfielder picking up a straight red card in the home defeat to Real Madrid last time out.
Athletic Bilbao possible starting lineup:
Simon; Balenziaga, I Martinez, Yeray, Lekue; Berenguer, D Garcia, Vencedor, Muniain; Williams, R Garcia
Granada possible starting lineup:
Maximiano; Quini, Torrente, Sanchez, Neva; Suarez, Gonalons, Eteki, Puertas; Soro, Molina
We say: Athletic Bilbao 2-1 Granada
Athletic are due a victory in Spain's top flight, and we believe that the home side will triumph here. Granada had started to show improvement before losing back-to-back matches, but Athletic should have enough to pick up an important three points at San Mames.
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