The champions of Spain, France and Netherlands are all in action on Friday night, headlined by Atletico Madrid's meeting with Cadiz.
Lille face Saint-Etienne in Ligue 1 and Ajax visit Cambuur in the Eredivisie, while there is also a Championship clash between West Bromwich Albion and Huddersfield Town.
Below is Sports Mole's selection of predictions and previews for today's and tomorrow's fixtures.
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| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Manchester CityMan City | 28 | 22 | 3 | 3 | 68 | 18 | 50 | 69 |
| 2 | Liverpool | 27 | 19 | 6 | 2 | 71 | 20 | 51 | 63 |
| 3 | Chelsea | 27 | 16 | 8 | 3 | 56 | 19 | 37 | 56 |
| 4 | Arsenal | 25 | 15 | 3 | 7 | 41 | 29 | 12 | 48 |
| 5 | Manchester UnitedMan Utd | 28 | 13 | 8 | 7 | 45 | 38 | 7 | 47 |
| 6 | West Ham UnitedWest Ham | 28 | 13 | 6 | 9 | 46 | 35 | 11 | 45 |
| 7 | Tottenham HotspurSpurs | 26 | 14 | 3 | 9 | 40 | 32 | 8 | 45 |
| 8 | Wolverhampton WanderersWolves | 28 | 13 | 4 | 11 | 28 | 23 | 5 | 43 |
| 9 | Aston Villa | 27 | 11 | 3 | 13 | 40 | 37 | 3 | 36 |
| 10 | Southampton | 28 | 8 | 11 | 9 | 35 | 43 | -8 | 35 |
| 11 | Crystal Palace | 28 | 7 | 12 | 9 | 39 | 38 | 1 | 33 |
| 12 | Leicester CityLeicester | 25 | 9 | 6 | 10 | 40 | 43 | -3 | 33 |
| 13 | Brighton & Hove AlbionBrighton | 27 | 7 | 12 | 8 | 26 | 32 | -6 | 33 |
| 14 | Newcastle UnitedNewcastle | 27 | 7 | 10 | 10 | 32 | 47 | -15 | 31 |
| 15 | Brentford | 28 | 7 | 6 | 15 | 30 | 45 | -15 | 27 |
| 16 | Leeds UnitedLeeds | 28 | 5 | 8 | 15 | 29 | 64 | -35 | 23 |
| 17 | Everton | 25 | 6 | 4 | 15 | 28 | 46 | -18 | 22 |
| 18 | Burnley | 26 | 3 | 12 | 11 | 22 | 36 | -14 | 21 |
| 19 | Watford | 28 | 5 | 4 | 19 | 27 | 54 | -27 | 19 |
| 20 | Norwich CityNorwich | 28 | 4 | 5 | 19 | 17 | 61 | -44 | 17 |
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | EibarEibar | 30 | 17 | 8 | 5 | 44 | 32 | 12 | 59 |
| 2 | Almeria | 30 | 18 | 4 | 8 | 47 | 25 | 22 | 58 |
| 3 | Real Valladolid | 30 | 17 | 7 | 6 | 50 | 30 | 20 | 58 |
| 4 | TenerifeTenerife | 30 | 15 | 7 | 8 | 41 | 25 | 16 | 52 |
| 5 | PonferradinaPonferradina | 30 | 13 | 10 | 7 | 40 | 33 | 7 | 49 |
| 6 | GironaGirona | 30 | 13 | 7 | 10 | 41 | 33 | 8 | 46 |
| 7 | CartagenaCartagena | 30 | 13 | 4 | 13 | 41 | 41 | 0 | 43 |
| 8 | UD Ibiza | 30 | 10 | 12 | 8 | 39 | 35 | 4 | 42 |
| 9 | Burgos | 30 | 12 | 5 | 13 | 34 | 30 | 4 | 41 |
| 10 | Real Oviedo | 30 | 9 | 14 | 7 | 34 | 31 | 3 | 41 |
| 11 | Las PalmasLas Palmas | 30 | 10 | 11 | 9 | 37 | 36 | 1 | 41 |
| 12 | LugoLugo | 30 | 8 | 16 | 6 | 36 | 33 | 3 | 40 |
| 13 | Leganes | 30 | 10 | 10 | 10 | 34 | 33 | 1 | 40 |
| 14 | Real ZaragozaZaragoza | 30 | 8 | 15 | 7 | 27 | 30 | -3 | 39 |
| 15 | Huesca | 30 | 9 | 11 | 10 | 36 | 30 | 6 | 38 |
| 16 | Malaga | 30 | 9 | 9 | 12 | 27 | 44 | -17 | 36 |
| 17 | Sporting GijonSporting Gijon | 30 | 9 | 8 | 13 | 33 | 37 | -4 | 35 |
| 18 | MirandesMirandes | 30 | 9 | 6 | 15 | 37 | 48 | -11 | 33 |
| 19 | Real Sociedad B | 30 | 7 | 8 | 15 | 28 | 38 | -10 | 29 |
| 20 | Amorebieta | 30 | 4 | 14 | 12 | 34 | 48 | -14 | 26 |
| 21 | Fuenlabrada | 30 | 4 | 14 | 12 | 24 | 38 | -14 | 26 |
| 22 | AlcorconAlcorcon | 30 | 2 | 8 | 20 | 23 | 57 | -34 | 14 |
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