England could guarantee their place at the 2022 World Cup when they host Albania in the latest round of UEFA World Cup qualifiers, while it is also a crucial night for Scotland's hopes of reaching Qatar.
Italy go head to head with Switzerland in a crunch match in Group C, while in South America bitter rivals Uruguay and Argentina face off.
Below is Sports Mole's selection of previews and predictions for Friday and Saturday.
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| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Chelsea | 11 | 8 | 2 | 1 | 27 | 4 | 23 | 26 |
| 2 | Manchester CityMan City | 11 | 7 | 2 | 2 | 22 | 6 | 16 | 23 |
| 3 | West Ham UnitedWest Ham | 11 | 7 | 2 | 2 | 23 | 13 | 10 | 23 |
| 4 | Liverpool | 11 | 6 | 4 | 1 | 31 | 11 | 20 | 22 |
| 5 | Arsenal | 11 | 6 | 2 | 3 | 13 | 13 | 0 | 20 |
| 6 | Manchester UnitedMan Utd | 11 | 5 | 2 | 4 | 19 | 17 | 2 | 17 |
| 7 | Brighton & Hove AlbionBrighton | 11 | 4 | 5 | 2 | 12 | 12 | 0 | 17 |
| 8 | Wolverhampton WanderersWolves | 11 | 5 | 1 | 5 | 11 | 12 | -1 | 16 |
| 9 | Tottenham HotspurSpurs | 11 | 5 | 1 | 5 | 9 | 16 | -7 | 16 |
| 10 | Crystal Palace | 11 | 3 | 6 | 2 | 15 | 14 | 1 | 15 |
| 11 | Everton | 11 | 4 | 3 | 4 | 16 | 16 | 0 | 15 |
| 12 | Leicester CityLeicester | 11 | 4 | 3 | 4 | 16 | 18 | -2 | 15 |
| 13 | Southampton | 11 | 3 | 5 | 3 | 10 | 12 | -2 | 14 |
| 14 | Brentford | 11 | 3 | 3 | 5 | 13 | 14 | -1 | 12 |
| 15 | Leeds UnitedLeeds | 11 | 2 | 5 | 4 | 11 | 18 | -7 | 11 |
| 16 | Aston Villa | 11 | 3 | 1 | 7 | 14 | 20 | -6 | 10 |
| 17 | Watford | 11 | 3 | 1 | 7 | 12 | 19 | -7 | 10 |
| 18 | Burnley | 11 | 1 | 5 | 5 | 11 | 17 | -6 | 8 |
| 19 | Newcastle UnitedNewcastle | 11 | 0 | 5 | 6 | 12 | 24 | -12 | 5 |
| 20 | Norwich CityNorwich | 11 | 1 | 2 | 8 | 5 | 26 | -21 | 5 |
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Chelsea | 11 | 8 | 2 | 1 | 27 | 4 | 23 | 26 |
| 2 | Manchester CityMan City | 11 | 7 | 2 | 2 | 22 | 6 | 16 | 23 |
| 3 | West Ham UnitedWest Ham | 11 | 7 | 2 | 2 | 23 | 13 | 10 | 23 |
| 4 | Liverpool | 11 | 6 | 4 | 1 | 31 | 11 | 20 | 22 |
| 5 | Arsenal | 11 | 6 | 2 | 3 | 13 | 13 | 0 | 20 |
| 6 | Manchester UnitedMan Utd | 11 | 5 | 2 | 4 | 19 | 17 | 2 | 17 |
| 7 | Brighton & Hove AlbionBrighton | 11 | 4 | 5 | 2 | 12 | 12 | 0 | 17 |
| 8 | Wolverhampton WanderersWolves | 11 | 5 | 1 | 5 | 11 | 12 | -1 | 16 |
| 9 | Tottenham HotspurSpurs | 11 | 5 | 1 | 5 | 9 | 16 | -7 | 16 |
| 10 | Crystal Palace | 11 | 3 | 6 | 2 | 15 | 14 | 1 | 15 |
| 11 | Everton | 11 | 4 | 3 | 4 | 16 | 16 | 0 | 15 |
| 12 | Leicester CityLeicester | 11 | 4 | 3 | 4 | 16 | 18 | -2 | 15 |
| 13 | Southampton | 11 | 3 | 5 | 3 | 10 | 12 | -2 | 14 |
| 14 | Brentford | 11 | 3 | 3 | 5 | 13 | 14 | -1 | 12 |
| 15 | Leeds UnitedLeeds | 11 | 2 | 5 | 4 | 11 | 18 | -7 | 11 |
| 16 | Aston Villa | 11 | 3 | 1 | 7 | 14 | 20 | -6 | 10 |
| 17 | Watford | 11 | 3 | 1 | 7 | 12 | 19 | -7 | 10 |
| 18 | Burnley | 11 | 1 | 5 | 5 | 11 | 17 | -6 | 8 |
| 19 | Newcastle UnitedNewcastle | 11 | 0 | 5 | 6 | 12 | 24 | -12 | 5 |
| 20 | Norwich CityNorwich | 11 | 1 | 2 | 8 | 5 | 26 | -21 | 5 |
