Sessegnon will be out for "a while" with a hamstring problem, Nuno Espirito Santo recently confirmed, while Doherty is working his way back from a knock but is unlikely to be involved so soon.
Both men would have been eyeing starts in this fixture, but Santo otherwise has no fresh injury concerns and will take this opportunity to rotate in all areas of the pitch, even with a cup quarter-final at stake.
Cristian Romero could hold his place in the centre of defence alongside a new partner in Davinson Sanchez, and it would not be a surprise to see Pierre-Emile Hojbjerg and Oliver Skipp both reprise their roles in midfield.
Son Heung-min may be sacrificed despite boasting four goals from his last six EFL Cup starts, while 17-year-old Dane Scarlett is unlikely to push Harry Kane for a start up top against Premier League opposition.
Tottenham possible starting lineup: Gollini; Tanganga, Romero, Sanchez, Davies; Hojbjerg, Skipp, Alli; Gil, Kane, Bergwijn body check tags ::