The Lilywhites were also made to work for their spot in this stage of the EFL Cup, with Nuno's old side Wolverhampton Wanderers holding Spurs to a 2-2 draw before the North London side produced the goods in the penalty shootout.
Here, Sports Mole rounds up all of Tottenham's latest injury and suspension news ahead of the contest.
Type of injury: Hamstring
Possible return date: Unknown
Ryan Sessegnon would have hoped to earn some valuable minutes in this contest, but Santo has admitted that the youngster will be out for "a while" longer with his hamstring injury, ruling him out of this contest.
Status: Major doubt
Type of injury: Knock
Possible return date: October 27 (vs. Burnley)
Matt Doherty suffered a knock during the most international break, and while Santo is hopeful that the right-back can rejoin training this week, this game may still come too soon for him.
TOTTENHAM'S SUSPENSION LIST
Spurs have no players suspended for this match.
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