Alaves vs. Atletico (Saturday, 1.00pm)
The defending champions netted a late winner to take all three points against Getafe last time out, while their hosts are yet to pick up a result from their opening five games of the season.
We say: Alaves 0-3 Atletico Madrid
While Los Colchoneros have not been overly convincing so far, we can only see their talented squad coming out of Saturday's game with a dominant victory.
With the hosts only netting one goal so far, Simeone's defence should not be overly troubled, while they boast a quality-filled attacking line that is more than capable of running riot of the basement side.
Valencia vs. Athletic Bilbao (Saturday, 3.15pm)
The hosts were handed a 3-1 loss by Sevilla on Wednesday, while the Basque outfit fell short against newly-promoted Rayo Vallecano.
We say: Valencia 1-1 Athletic Bilbao
Both sides boast strong squads and will be keen to bounce back from defeats after relatively impressive starts, and we cannot quite pick a winner.
With the hosts showing impressive ability going forward and the Basque side thriving defensively, this will certainly be an intriguing affair, and we are opting for a relatively low-scoring draw on Saturday.
Sevilla vs. Espanyol (Saturday, 5.30pm)
Sevilla will look to continue their strong start to the La Liga season on Saturday, when they welcome newly-promoted Espanyol to the Ramon Sanchez Pizjuan Stadium.
Julen Lopetegui's side continued their unbeaten run with a 3-1 victory over Valencia last time out, while the visitors recorded their first win of the season on Wednesday.
We say: Sevilla 2-0 Espanyol
While Espanyol have shown plenty of positive signs this season, we do not expect them to get a result from a tough trip to an unbeaten Sevilla side on Saturday.
Lopetegui has coached an impressive defensive line, while their attacking ranks should have more than enough to break the newly-promoted outfit down.
Real Madrid vs. Villarreal (Saturday, 8.00pm)
Los Blancos are currently top of the table, having picked up 16 points from their opening five matches, while Villarreal sit 11th with seven points to show from their first five league games of the season.
We say: Real Madrid 2-1 Villarreal
This is a potential banana skin for Real Madrid, with Villarreal certainly capable of picking up a positive result. Ancelotti's side will be full of confidence due to their impressive form, though, and we are backing the capital side to put another important three points on the board here.