Elche vs. Real Madrid (Saturday, 1.00pm)
We say: Elche 1-3 Real Madrid
Elche are capable of making this a tricky afternoon for Real Madrid, who struggled to get going against Osasuna last time out. Los Blancos will be determined to return to winning ways, though, and we are finding it very difficult to predict anything other than a routine victory for the title hopefuls.
Sevilla vs. Osasuna (Saturday, 3.15pm)
Having lost one game all season, Sevilla will be hoping this is the year they end their 75-year wait for a Spanish title.
We say: Sevilla 2-1 Osasuna
There have been plenty of encouraging signs for Sevilla so far this season but extending their title challenge across a full campaign will prove tricky.
If they want to maintain ambitions of a famous La Liga title win, it is wins against the likes of Osasuna that could define their hopes.
Valencia vs. Villarreal (Saturday, 5.30pm)
Separated by less than an hour, the two are also near-neighbours in the table, with Villarreal one point and one place behind Valencia.
We say: Valencia 1-1 Villarreal
Neither side can really afford another defeat, meaning this encounter will likely see both sides go for the three points.
Ironically, that could see the pair cancel each other out, so do not be surprised to see another stalemate in a season already full of draws for the two.
Barcelona vs. Alaves (Saturday, 8.00pm)
The Catalan giants sacked Koeman as head coach following Wednesday's 1-0 loss to Rayo Vallecano, and Barcelona B boss Sergi Barjuan has been appointed as first-team manager on an interim basis.
We say: Barcelona 3-1 Alaves
For all of Barcelona's problems this season, there is still so much quality in their squad. Alaves will be feeling good about themselves after successive victories, but we believe that the home side will return to winning ways in relatively routine fashion.