Kylian Mbappe surprisingly started and played the full 90 against Lyon after rapidly overcoming a foot problem, and the Frenchman provided the assist for Mauro Icardi's dramatic late winner against Les Gones.
Icardi will certainly hope that his heroics have earned him a place in the first XI here, and given Mbappe's fitness woes this season, Pochettino may take this opportunity to rest the attacker.
Lionel Messi was clearly not impressed with his second-half substitution at the weekend as he snubbed Pochettino's handshake, and the ex-Barcelona man is now confirmed to be missing out with bone bruising, so Icardi could start in between Angel Di Maria and Neymar.
Ander Herrera could not keep up his goalscoring streak against Lyon but should retain his place in the middle of the park given his form over the past couple of weeks, although he may find himself partnered by a new faces in Leandro Paredes and Georginio Wijnaldum if Idrissa Gueye is rested.
It remains to be seen if Sergio Ramos will be passed fit for this encounter as previous reports suggested, but Marquinhos and Presnel Kimpembe should continue as the first-choice pairing in front of Gianluigi Donnarumma for now.
PSG possible starting lineup: Donnarumma; Hakimi, Marquinhos, Kimpembe, Diallo; Paredes, Herrera, Wijnaldum; Di Maria, Icardi, Neymar