The Manchester United returnee left the camp early in order to link up with his Old Trafford teammates and also missed the recent 3-1 friendly victory over next year's hosts Qatar on Saturday.
However, Ronaldo's shirt-stripping celebration against the Republic of Ireland - during which he became the greatest international goalscorer in the history of the men's game - means that he is suspended anyway, so Andre Silva could keep his place up top after netting against Qatar.
Fernando Santos unsurprisingly made a whole contingent of changes at the weekend and will revert to his strongest XI here, with Joao Mario, Joao Moutinho and Ruben Neves all making way for Bruno Fernandes, Bernardo Silva and Joao Palhinha.
Joao Cancelo and Raphael Guerreiro are also in line to replace Nelson Semedo and Nuno Mendes in the full-back areas, while Rui Patricio is set for his 99th international cap as Anthony Lopes prepares to be demoted to the bench.
Portugal possible starting lineup: Patricio; Cancelo, Dias, Pepe, Guerreiro; Palhinha, B. Silva, Fernandes; R. Silva, A. Silva, Jota body check tags ::