Manchester City's Ruben Dias is out of the contest through injury, so Danilo is again likely to feature alongside Pepe in the middle of the defence, although David Carmo and Domingos Duarte are also options.
Bruno Fernandes and Bernardo Silva are likely to be joined by Joao Moutinho in midfield, although Ruben Neves, William Carvalho and Joao Palhinha are also pushing for starts in the UEFA Nations League contest.
Ronaldo missed Manchester United's final match of the 2021-22 Premier League campaign due to a hip problem but is available to start for his country on Thursday night.
Portugal possible starting lineup: Patricio; Cancelo, Pepe, Danilo, Guerreiro; Fernandes, Moutinho, Bernardo; Otavio, Ronaldo, Jota
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