While seven places and 14 points separate these two teams in the standings, Portsmouth will be back in contention for the top six with victory on the South Coast.
Oxford head into their next game as outsiders to gain automatic promotion, a consequence of trailing Wigan Athletic by four points having played three matches more.
Nevertheless, Karl Robinson's team remain with the best attacking record in the division after a 4-2 victory over Cambridge United at the weekend extended their winning streak to three matches.
Having conceded 13 times in nine games, there will be those who will insist that Oxford's defence must improve, but Robinson will be wary of upsetting the balance of a team which remains as a clear threat to the top two.
Although their away record has been slightly indifferent, seven wins have come from 17 games, their last two successes at Charlton Athletic and Crewe Alexandra also coming with shutouts.
At a time when Oxford have strengthened their position in the playoffs, Portsmouth have put together a much-needed four-game unbeaten streak.
Ten points have been collected during that period, the only draw coming on Saturday as Danny Cowley's side remarkably came back from a three-goal deficit to earn a share of the spoils against Fleetwood Town.
With Fleetwood down in 19th position, it could be regarded as two points dropped, but two goals in the final 10 minutes means that the momentum is with Pompey.
While the South-Coast outfit currently sit 10 points adrift of the playoffs, their matches in hand makes things interesting, providing that they can keep ticking over with another strong result in front of their own supporters.
Ronan Curtis will miss out for Portsmouth after collecting his 10th yellow card of the season at the weekend.
Barring any injury issues, the remainder of the team could stay the same.
While Robinson could also stick with the 11 players which started against Cambridge United, Brannagan is one yellow card away from a two-match ban.
Marcus Browne is an alternative after his 14-minute cameo at the weekend, although Brannagan is more likely to retain his spot in the team.
Portsmouth possible starting lineup:
Bazunu; Carter, Raggett, Robertson; Harness, Tunnicliffe, Morrell, Hume; Hackett-Fairchild; Hirst, Walker
Oxford United possible starting lineup:
Stevens; Williams, McNally, Long, Seddon; Sykes, Kane, Brannagan; Whyte; Baldock, Taylor
We say: Portsmouth 1-1 Oxford United
Aside from the runaway leaders Rotherham United, these two clubs are the form sides in the divisions, and it should make for an entertaining spectacle. All things considered, Pompey need three points, but we feel that Oxford will do enough to earn a share of the spoils.
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