The Rams, meanwhile, are searching for just their fourth league win of the campaign and their first since beating Reading in September.
Millwall's impressive run of form in the Championship continued with a slender 1-0 victory at home against Reading on Tuesday night.
After a goalless first half, the deadlock was eventually broken in the 71st minute when Benik Afobe tapped in from close range to seal all three points for the Lions for the sixth time this season.
Millwall, who have now won five of their last seven league games, have climbed up to ninth in the table, just one point behind Queens Park Rangers and Stoke City in the playoffs.
Gary Rowett is now preparing to face his former side Derby County, who have beaten the Lions in their last two meetings at The Den, including a 1-0 win for the Rams last season.
The 47-year-old will be looking to improve his managerial record against Derby, as he has only won one of his five league matches at home against them, accumulating just four points from a possible 15 available.
Derby extended their unwanted winless run in the Championship to six matches when they were beaten 2-1 away against relegation rivals Barnsley on Wednesday night.
Sam Baldock tucked away his effort from close range to put the Rams in front midway through the first half, however the Tykes were able to turn the game on its head with strikes either side of half time from Victor Adeboyejo and Aaron Leya Iseka.
Wayne Rooney's men remain at the bottom of the table with just five points and are still seven points adrift of safety.
Derby's form will need to improve quickly if they are to edge themselves out of the relegation zone, but with tricky encounters against Bournemouth, Fulham and Queens Park Rangers to follow Saturday's trip to Millwall, their chances of ending their winless run may be slim.
However, one hopeful statistic for Rooney's men heading to the capital is that the away team have won each of the last five league meetings between Millwall and Derby, with each victory coming by a one-goal margin. The Rams have also won three of their last four away matches against sides from London so they can take some confidence into this weekend's fixture.
Millwall's only absentee for Saturday's game is midfielder George Evans, who continues to recover from a broken hand.
Like the Lions, Derby also have only one player unavailable, with Krystian Bielik ruled out for at least a few more weeks with a knee injury.
Millwall possible starting lineup:
Bialkowski; Leonard, Hutchinson, Cooper, Wallace; Saville, Kieftenbeld, Mitchell; Wallace, Smith, Afobe
Derby County possible starting lineup:
Roos; Byrne, Jagielka, Davies, Buchanan; Morrison, Bird, Shinnie, Lawrence; Kazim-Richards, Baldock
We say: Millwall 1-0 Derby County
Each of the last four games involving Derby have seen both teams score, however we are expecting a low-scoring cagey affair at The Den.
Considering the form of both sides heading into Saturday's match, the hosts should be able to do enough to edge out the Rams on home soil.
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