Mansfield and Newcastle Under-21s are third and fourth respectively in the section, with the two sides both losing to Harrogate Town and Sheffield Wednesday in their opening two fixtures.
Mansfield made it back-to-back wins on Saturday afternoon, as they managed to advance to the second round of the FA Cup courtesy of a surprise 1-0 win over Sunderland, with Rhys Oates's early effort proving to be the difference between the two sides at the Stadium of Light.
It would be fair to say that the EFL Trophy is down the list of priorities for the club this season, and they have found it difficult to compete in this particular section, opening with a 3-1 defeat at Harrogate at the end of August before going down 2-1 at home to Sheffield Wednesday towards the start of October.
Mansfield have actually lost five of their last six matches in this competition and will have their eyes firmly on their next League Two contest, which comes away to Stevenage on November 13.
There will still be pride at stake on Tuesday night, though, and having posted victories in their last two matches, the home side will be keen to put another win on the board in front of their own supporters.
Newcastle Under-21s, meanwhile, were on the end of a 3-0 defeat at Sheffield Wednesday in their opening match of the competition at the end of August, with the Owls scoring twice in the early stages of the second period to take the match away from the visitors.
Newcastle Under-21s have now lost each of their last nine matches in the EFL Trophy and will be desperate to end that disappointing run of form on Tuesday night, proving that they can compete at this level in the process.
Mansfield boss Clough will certainly make changes to the side that started the impressive 1-0 win over Sunderland at the Stadium of Light on Saturday afternoon.
Jordan Bowery came off the bench in Saturday's FA Cup success, meanwhile, and will be another hoping to earn some minutes in the EFL Trophy fixture.
As for Newcastle Under-21s, their starting side is expected to be similar to the one that took to the field for the first whistle against Harrogate in North Yorkshire on October 5.
Mansfield Town possible starting lineup:
Shelvey; Clarke, Cooper, Rawson, Burke; Charsley, Ward, Law, Quinn; Sinclair, Johnson
Newcastle United Under-21s possible starting lineup:
Gillespie; Oliver, Wiggett, Savage, Cross; Young, Brookwell; White, Anderson, Scott; Stephenson
We say: Mansfield Town 2-1 Newcastle United Under-21s
Mansfield's team will be very different to the one that started on Saturday, but the hosts will still fancy their chances of overcoming a youthful Newcastle Under-21s outfit, and we are expecting Clough's side to pick up their first three points of this season's tournament in this match.
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