Southampton vs. Man Utd (Sunday, 2.00pm)
Manchester United will be looking to make it back-to-back wins at the start of their 2021-22 Premier League season when they head to St Mary's on Sunday afternoon to face Southampton.
The Red Devils opened their campaign with a 5-1 home victory over Leeds United last weekend, while Southampton suffered a 3-1 defeat to Everton at Goodison Park in their first game of the season.
We say: Southampton 1-3 Manchester United
Southampton are more than capable of making this a tricky match for Man United, but we are finding it difficult to back against the visitors taking everything into consideration. Solskjaer's side will be flying after hitting five against Leeds and should have too much for the Saints on Sunday afternoon.
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> How Manchester United could line up against Southampton
> Man United injury, suspension list vs. Southampton
Wolves vs. Spurs (Sunday, 2.00pm)
Tottenham Hotspur will be looking to make it back-to-back wins at the start of their 2021-22 Premier League season when they travel to Molineux on Sunday to take on Wolverhampton Wanderers.
Spurs opened their campaign with an impressive 1-0 victory over the champions Manchester City last weekend, while Wolves began life under new head coach Bruno Lage with a 1-0 loss at Leicester City.
We say: Wolverhampton Wanderers 1-1 Tottenham Hotspur
Spurs will be on a high after their win over Man City, but Wolves were impressive in stages of their defeat to Leicester, and we are predicting a low-scoring draw on Sunday afternoon, which would not be the worst result in the world for either side.
> Click here to read our full preview for this match
> How Tottenham Hotspur could line up against Wolves
Arsenal vs. Chelsea (Sunday, 4.30pm)
A tantalising London derby takes place in gameweek two of the new Premier League season, as Arsenal and Chelsea face off at the Emirates Stadium on Sunday afternoon.
The Gunners opened the new campaign with a dismal 2-0 defeat at Brentford last Friday, whereas Thomas Tuchel's side eased to a 3-0 success over Crystal Palace.
We say: Arsenal 1-2 Chelsea
Arsenal certainly have some bright young talent in their attacking ranks, but after experiencing very little joy against Brentford, a similar story is likely to follow against the champions of Europe.
With Lukaku out to score his first ever goal for Chelsea and the Blues seeking to avenge back-to-back defeats last season, we can only see the blue side of London celebrating after Sunday's game.
> Click here to read our full preview for this match
> How Chelsea could line up against Arsenal
> How Arsenal could line up against Chelsea
> Chelsea injury, suspension list vs. Arsenal
> Arsenal injury, suspension list vs. Chelsea
> How Arsenal could line up against Chelsea with Odegaard, Ramsdale
