Watford vs. Liverpool (Saturday, 12.30pm)
We say: Watford 1-3 Liverpool
With Liverpool shipping five goals in their last two Premier League games and set to be without two mainstays of the side due to late arrivals back to the UK, it would not be surprising to see Watford enjoy some good fortunes up top in Ranieri's inaugural fixture.
However, the Reds' sheer quality in the final third should come to the fore once more, and while Klopp has some big decisions to make amid a taxing schedule, we can only see Liverpool prevailing comfortably.
Aston Villa vs. Wolves (Saturday, 3.00pm)
Dean Smith's side suffered a 2-1 defeat to Tottenham Hotspur just before the international break, while Wolves marched to a 2-1 win over Newcastle United.
We say: Aston Villa 1-1 Wolverhampton Wanderers
With both managers facing selection dilemmas due to injuries and late arrivals back from international duty, a cagey affair could be in store during another low-scoring derby between the pair.
Villa have no problem finding the back of the net on home soil, but a Hwang-inspired Wolves are beginning to build momentum and can realistically harbour hopes of a point at Villa Park.
Leicester vs. Man Utd (Saturday, 3.00pm)
The Red Devils are currently fourth in the table, with 14 points to show from their opening seven matches of the season, while Leicester sit down in 13th, picking up just eight points from seven games this term.
We say: Leicester City 1-2 Manchester United
Leicester's overall form this season has to be taken into account when picking a prediction here. A draw would not be a surprise, and the Foxes are, of course, also more than capable of winning it, but Man United are so strong on their travels, and we believe that the Red Devils will just about do enough to record a narrow victory at the King Power Stadium.
Man City vs. Burnley (Saturday, 3.00pm)
Manchester City will aim to make an immediate return to winning ways in the Premier League when they take on Burnley at the Etihad on Saturday afternoon.
The reigning champions played out a pulsating 2-2 draw with Liverpool last time out, while Sean Dyche's side could only take a point from their clash with Norwich City.
We say: Manchester City 3-0 Burnley
Burnley may have developed a new-found sense of resilience following two successive draws in the top flight, but their four most recent trips to the Etihad have all ended in disaster against a five-star City.
It is difficult to see Guardiola's side repeating the same trick again given how the international break will take its toll, but this ought to be another routine success and clean sheet for the champions either way.
Norwich vs. Brighton (Saturday, 3.00pm)
Brighton & Hove Albion will be looking to continue their excellent start to the 2021-22 Premier League season when they head to Carrow Road to face Norwich City on Saturday afternoon.
The Seagulls are currently sixth in the table, picking up 14 points from their opening seven matches, while Norwich sit bottom, having collected just one point from their first seven games of the season.
We say: Norwich City 1-2 Brighton & Hove Albion
Norwich will be looking to build on their draw against Burnley before the international break, but the Canaries will be coming up against an in-form Brighton outfit. We are expecting a close match at Carrow Road but have just settled on an away victory, with Brighton potentially being the surprise package of the 2021-22 campaign.
Southampton vs. Leeds (Saturday, 3.00pm)
Leeds United will be looking to make it back-to-back wins in the Premier League when they head to St Mary's on Saturday afternoon to take on Southampton.
The Whites are currently 16th in the table, having picked up six points from their opening seven matches, while Southampton occupy 17th, two points behind their opponents in this game.
We say: Southampton 2-2 Leeds United
This has all of the makings of a very open game of football, and we are predicting goals on Saturday. Southampton will be desperate to record their first league win of the campaign, but we cannot see the Saints overcoming Leeds, who put a very important three points on the board before the international break.
Brentford vs. Chelsea (Saturday, 5.30pm)
Thomas Tuchel's side eased past Southampton before the international break, while the Bees got the better of West Ham United 2-1.
We say: Brentford 1-2 Chelsea
The potential loss of Lukaku will undoubtedly hurt Chelsea this weekend, and the leaders can take nothing for granted against a Brentford side fired up in front of their own fans.
Tuchel has far more fitness concerns to deal with than he would have liked at this stage, and while we still expect the Blues to just about pull through, Frank's side are sure to give them a scare or two.