The Red Devils meet Villa for the second time in the space of a week, having beaten Steven Gerrard's side 1-0 in the FA Cup at Old Trafford on Monday night.
Man United will now make the return trip looking to extend an unbeaten record at Villa Park which stretches back to a 3-0 League Cup defeat in October 1999.
Since then, Man United are unbeaten in 22 away games against Aston Villa, winning 17 and drawing five - just one game short of the all-time English football record when both sides have been in the top four tiers.
Only Liverpool have had a longer such unbeaten streak, going 23 without defeat away to Sunderland between 1959 and 2002.
Villa's record in the league alone is no better as they are 22 top-flight home games without a win against Man United since 1995 - the longest such streak in Football League history.
Another victory for the 20-time champions on Saturday would see them record their 300th Premier League away win too, a landmark no other team has achieved in the competition's history.