Spurs suffered a 1-0 defeat at West Ham United in the league last time out, while Man United were beaten 5-0 at home by Liverpool, and here Sports Mole rounds up the team news for the two sides this weekend.
Out: Ryan Sessegnon (hamstring)
Doubtful: Bryan Gil (hamstring)
Sports Mole's predicted XI: Lloris; Emerson, Romero, Dier, Reguilon; Skipp, Hojbjerg; Lucas, Ndombele, Son; Kane
Out: Paul Pogba (suspended)
Sports Mole's predicted XI: De Gea; Wan-Bissaka, Varane, Maguire, Shaw; Matic, Fred; Sancho, Fernandes, Rashford; Ronaldo