The Red Devils held Chelsea to a 1-1 draw last time out, while Mikel Arteta's side beat Newcastle United 2-0, and here Sports Mole rounds up the team news for both clubs.
Doubtful: Luke Shaw (head)
Sports Mole's predicted XI: De Gea; Wan-Bissaka, Maguire, Lindelof, Telles; Matic, Fred, McTominay; Fernandes; Sancho, Ronaldo
Doubtful: Bukayo Saka (muscle)
Sports Mole's predicted XI: Ramsdale; Tomiyasu, White, Gabriel, Tavares; Partey, Lokonga; Martinelli, Odegaard, Smith Rowe; Aubameyang