As a result, Keylor Navas should hold his place in between the sticks, despite seeing red in the 3-1 win over Nantes in Ligue 1 at the weekend.
Marquinhos and Presnel Kimpembe were not involved in that game, but the duo are in training and will expect to form the centre-back pairing here, and Sergio Ramos also has a strong chance of making his long-awaited debut.
Nuno Mendes is in line to replace Juan Bernat at left-back as Achraf Hakimi retains his spot on the right, while Idrissa Gueye is set to protect the back four after opening the scoring in September's 2-0 win over City.
Leandro Paredes has overcome a thigh issue but could drop out for Georginio Wijnaldum - who scored both of his side's goals in the 2-2 draw with Leipzig last month - as Marco Verratti holds his place as expected.
Lionel Messi finally got off the mark for the new Ligue 1 season at the sixth attempt in the win over Nantes, and the six-time Ballon d'Or winner will form a part of the famed triumvirate with Neymar and Kylian Mbappe at the Etihad.
PSG possible starting lineup: Navas; Hakimi, Marquinhos, Kimpembe, Mendes; Verratti, Gueye, Wijnaldum; Messi, Mbappe, Neymar