Die Mannschaft have won all four games since Flick took charge after Euro 2020, including a 2-1 victory over Romania on Friday, but lost to North Macedonia in the reverse fixture back in March when under the tutelage of Joachim Low.
Flick's starting XI on this occasion will be significantly different to that game, but also likely tweaked since Friday's win.
Manuel Neuer was ruled out with a groin injury in the build up to the game, with Marc-Andre ter Stegen stepping up to fill the void and the Barcelona stopper will likely retain his spot with captain Neuer not suitably recovered just yet.
That will leave no space once again for Bayer Leverkusen's young prodigy Florian Wirtz, but the 18-year-old will be hopeful of some minutes from the bench after not featuring at all in the Romania game.
Germany currently have eight players who are one booking away from a one-match ban - a couple of those are not in the current squad, but Antonio Rudiger, Thilo Kehrer and Kimmich, in particular, will need to be careful.
Germany possible starting lineup:
Ter Stegen; Hofmann, Sule, Rudiger, Kehrer; Kimmich, Goretzka; Sane, Muller, Gnabry; Havertz body check tags ::