The two sides meet for the first time since 1997-98 when Les Gones secured a 7-3 aggregate victory in the first round of the UEFA Cup.
Lyon claimed all three points in their opening group game when they beat Scottish Premiership champions Rangers 2-0 at Ibrox earlier this month.
Since that victory, Lyon have claimed just four points from a possible nine available in Ligue 1. Peter Bosz's men suffered a 2-1 defeat away against league leaders Paris Saint-Germain – conceding in the 93rd minute – before beating Troyes 3-1 on home soil and drawing 1-1 with 10 men against Lorient in their most recent match last weekend.
Les Gones now turn their attention back to the Europa League, a competition in which they have won 14 of their 19 matches at the Parc Olympique Lyonnais.
Lyon have also won all four of their matches in major European competitions against Danish opposition and they are expected to continue that run on Thursday against Group A outsiders Brondby.
Competing in their first major European competition since 2008-09, Brondby claimed a point against Czech outfit Sparta Prague in the opening group game, after both sides played out an uneventful goalless draw.
The reigning Danish Superliga champions have made a poor start to their title defence, winning just two of their first 10 league matches so far this season, with their most recent victory coming last weekend against Aalborg, a 2-1 win on home soil.
At such an early stage in the season, Niels Frederiksen's men currently languish in eighth place and are already 13 points behind league leaders FC Midtjylland.
Their form needs to improve quickly if they are to climb the Superliga table, however they face a challenging encounter in Europe on Thursday against Lyon, who are one of the favourites to win the Europa League this campaign.
Brondby have lost nine of their last 10 away games in major European competitions and they are also winless in each of their last four games against French opposition.
As for Brondby, centre-back Rasmus Wikstrom is set for a lengthy spell on the sidelines as he is suffering with a shoulder injury.
Paraguayan left-back Blas Riveros, who has been ruled out since November 2020 with a ruptured knee ligament injury, remains unavailable for selection though the 23-year-old is closing in on a full recovery.
Lyon possible starting lineup:
Lopes; Dubois, Diomande, Da Silva, Emerson; Caqueret, Guimaraes; Shaqiri, Paqueta, Aouar; Ekambi
Brondby possible starting lineup:
Hermansen; Borkeeiet, Maxso, Tshiembe; Bruus, Slimane, Radosevic, Frendrup, Mensah; Hedlund, Uhre
We say: Lyon 2-0 Brondby
Despite an inconsistent domestic run in recent weeks, and having several first-team players out injured, Lyon should be strong enough to beat Brondby on Thursday night.
The Danish visitors are enduring a poor run of form at present and their fortunes are unlikely to turn in France.
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