At a time when the Hatters went down 2-0 at Preston North End, Boro lost by the same scoreline at home to Birmingham City.
Having put together a five-match undefeated record in the second tier, Luton boss Nathan Jones will be frustrated with how his side fared at Deepdale.
The Welshman spoke openly about his disappointment on Saturday night, feeling that his squad had been given a wake-up call in their bid to remain in contention for promotion.
Nevertheless, Luton have already proven this season that they can bounce back with immediate effect, and home fixtures against Middlesbrough and Stoke City feel ideal ahead of the next international break.
That said, they need to show more ruthlessness at their home ground with just three wins coming from their seven outings on familiar territory.
On the flip side, Luton face opponents in Middlesbrough who have only scored five times during the same amount of fixtures on the road.
Neil Warnock would have been unconcerned by his side still failing to net more than twice in a game this season had they made it four successive wins against Birmingham.
However, their issues in front of goal led to another disappointing reverse, a result which has left the North-East outfit down in 11th position.
With just six points separating fifth and 19th place, the margins for error are small, and Warnock will recognise that his team need to respond against opponents who have collected the same amount of points.
Given that Boro have only posted back-to-back defeats on one occasion this season, the veteran boss will be optimistic that they can remain contenders for the top six.
Jones will consider making several changes to his Luton XI with Fred Onyedinma among those in contention for a recall.
Luke Berry is likely to miss out again having sustained a knee injury last week.
Luton Town possible starting lineup:
Sluga; Lockyer, Bradley, Naismith; Bree, Clark, Mpanzu, Bell; Onyedinma, Muskwe, Cornick
Middlesbrough possible starting lineup:
Lumley; McNair, Bamba, Peltier; Tavernier, Siliki, Howson, Crooks, Jones; Watmore, Sporar
We say: Luton Town 1-1 Middlesbrough
With this game pitting one of the best Championship attacks against one of the most resolute backlines, we expect a competitive encounter. Warnock will fancy Boro's chances of bouncing back, but we are backing Luton to earn a deserved share of the spoils.
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