Reds boss Jurgen Klopp surprisingly handed a start to Divock Origi in Wednesday's Champions League win over AC Milan, but the Belgian striker is sure to make way for Sadio Mane here after being taken off with cramp.
The Senegal international netted both of his side's goals in a 2-0 win over Palace on the final day of the 2020-21 Premier League season and will endeavour to score against the Eagles for the ninth Premier League game in a row this weekend.
Harvey Elliott begins the long road to recovery after undergoing surgery on a serious ankle injury, with Jordan Henderson taking over from his stricken compatriot and set to start alongside Fabinho once more.
Naby Keita was given the nod in the final midfield spot against Milan but could make way for Thiago Alcantara here, while James Milner and Alex Oxlade-Chamberlain are other midfield options for Klopp.
Liverpool possible starting lineup: Alisson; Alexander-Arnold, Van Dijk, Matip, Robertson; Fabinho, Henderson, Thiago; Salah, Jota, Mane