The Eagles travel to Merseyside having trounced 10-man Tottenham Hotspur 3-0 last weekend, with Wilfried Zaha netting from the penalty spot before Odsonne Edouard netted a brace off the bench on his debut.
Liverpool welcome Crystal Palace to Anfield on an eight-game winning run against the Eagles in the Premier League, but Klopp is expecting a challenging encounter this time around.
Speaking to the media ahead of Saturday's game, Klopp said: "Massive [difference] in Palace. A proper football side. Patrick has a clear idea of how to set up and use the players.
"Incredible how strong they are up front. Edouard came in and scored twice. Ayew, Benteke, Zaha...quality. Gallagher in midfield, a talent. They will do well, I am pretty sure, but we have to do well as well and hopefully we can do that."