The Azzurri currently sit joint top of Group C along with the Swiss on 14 points, and a victory against them next week would all but confirm their qualification for the 2022 tournament in Qatar.
Eight players who were not selected in October's squad have been called up by Mancini this month, including a first senior call up for Torino's 22-year-old midfielder Tommaso Pobega.
Cagliari goalkeeper Alessio Cragno has returned to the Italian squad for the first time since May, though the 27-year-old, along with Alex Meret and Salvatore Sirigu, are unlikely to displace first-choice stopper Gianluigi Donnarumma in the first XI.
Defensive trio Cristiano Biraghi, Davide Calabria and Gianluca Mancini have all been added to the squad, while Pobega, Nicolo Zaniolo and Sandro Tonali – who has been selected by the national team for the first time in a year – have all been selected to bolster Mancini's midfield options.
Paris Saint-Germain midfielder Marco Verratti has not been selected as he continues to recover from a hip injury, while Atalanta duo Matteo Pessina and Rafael Toloi have also been forced to pull out as they are both suffering with thigh problems.
Italy's first match with Switzerland will take place at the Stadio Olimpico on November 12, before Mancini's men travel to Belfast for their encounter with Northern Ireland three days later.