Inter Milan vs. Udinese (Sunday, 11.30am)
The third-placed Nerazzurri got back to winning ways in midweek, while their visitors endured a seventh straight winless game to slip closer to the Serie A drop zone.
We say: Inter Milan 3-0 Udinese
The pace is relentless at the top of Serie A this season, so only victory will do for Inter before they contest a much-anticipated derby clash with Milan next weekend.
All three points should be safely secured without too much fuss in Sunday's early kickoff, as Udinese may be relatively well organised but lack punch in the final third.
Fiorentina vs. Spezia (Sunday, 2.00pm)
While the Viola have won five and lost five so far this season, their Ligurian visitors are among the sides battling at the bottom of the table, with just two wins from their first 10 games.
We say: Fiorentina 2-1 Spezia
Fiorentina will certainly have the measure of opponents who have regressed since last term's impressive arrival on the Serie A stage - particularly with their manager having the inside track on his former Spezia side.
For that reason, the Viola will continue their record of having posted no draws so far this season and pick up a valuable three points before tougher tests to come.
Genoa vs. Venezia (Sunday, 2.00pm)
While the home side have not won a league fixture since September 12, the visitors have suffered back-to-back defeats in quick succession.
We say: Genoa 2-1 Venezia
While less time has passed since Venezia's last victory, we cannot ignore the amount of draws that have been recorded by Genoa. With that in mind, we are backing the home side to finally get back on track on Sunday, edging this contest by the odd goal in three.
Sassuolo vs. Empoli (Sunday, 2.00pm)
While the home side occupy ninth position in the Serie A standings, the visitors are two points adrift in 11th spot after a period of poor form.
We say: Sassuolo 3-1 Empoli
Having found some form of late, we can only back Sassuolo to prevail from this contest. While it may be a case of after the Lord Mayor's show for a time, their attacking quality should shine through at some stage.
Salernitana vs. Napoli (Sunday, 5.00pm)
A Campanian derby at Stadio Arechi will bring together the division's top side and one sitting 19th following their first away win of the season in midweek.
We say: Salernitana 0-2 Napoli
Failure to come out on top in this local rivalry - rarely staged over the past 20 years due to the gulf in stature between the clubs - would represent a major shock for Napoli.
However, their clear-minded and clinical approach under Luciano Spalletti will ensure that does not happen in Salerno, so they can add another three points to their spectacular tally before their return to continental competition on Thursday.
Roma vs. AC Milan (Sunday, 7.45pm)
Sitting some nine points above their capital city counterparts in the standings, the Rossoneri enter the weekend level on points with Napoli, as the pair lead the way in the early stages of the Scudetto race.
We say: Roma 1-1 AC Milan
Both teams have been adept at keeping opponents shut out - in domestic competition at least - so not much is likely to separate them throughout what is sure to be a hard-fought 90 minutes.
While a goalless draw must be a possibility, the array of attacking talent on display at the Olimpico will surely see someone unlock the door for either side as legs start to tire.