Roma vs. Genoa (Saturday, 2.00pm)
Continuing their pursuit of a European place for next season, Roma welcome crisis club Genoa to Stadio Olimpico on Saturday afternoon.
Before the last fortnight's hiatus, the Giallorossi had put together a three-match winning run between Serie A and the Coppa Italia, while their relegation-threatened visitors are without a victory in 20 games all told.
We say: Roma 2-0 Genoa
Although Genoa's winless run must eventually end, the likelihood of that happening at the Olimpico this week is minimal - even with a number of fresh faces to provide new attacking options.
Roma really must take advantage of a clear opportunity to take three more points on home turf, and their final-third quality will prove the difference on Saturday.
> Click here to read our full preview for this match
Inter Milan vs. AC Milan (Saturday, 5.00pm)
Seeking to extend a four-point advantage over AC Milan at the top of the Serie A standings, Inter Milan play 'hosts' in Saturday's Derby della Madonnina.
An incredible reversal in fortunes since the last Milan Derby, in November, sees Inter swap a seven-point deficit for the chance to establish the same lead themselves - if they can defeat their Rossonero rivals at San Siro.
We say: Inter Milan 2-1 AC Milan
Most markers point towards a 'home' win on Saturday, as Inter are again in the ascendancy and victory would establish a significant lead over Milan in the title race.
The Nerazzurri's attacking adaptability and greater strength in depth should help them overcome an increasingly inconsistent opposition side, which might even prove a knockout blow for the Rossoneri's Scudetto aspirations.
> Click here to read our full preview for this match
Fiorentina vs. Lazio (Saturday, 7.45pm)
Locked together on points in the Serie A standings, seventh-placed Fiorentina and Lazio - who sit eighth - convene at Stadio Artemio Franchi on Saturday.
While the Viola must recover from losing their top-scoring talisman at the end of the transfer window, their capital counterparts arrive in Florence looking to leapfrog the hosts with a win.
We say: Fiorentina 1-2 Lazio
The fallout from recent events at the Franchi - plus the need to observe a settling period for their new-look front line - could mean that Fiorentina are caught short in an absorbing encounter between two progressive teams.
Though no major signings have been made, Lazio can at least name a settled side - including the likeliest matchwinner: the in-form Immobile.
