Shakhtar started their Group D campaign with a 2-0 defeat at Sheriff Tiraspol on September 15, while Inter suffered a 1-0 home loss to Spanish giants Real Madrid in their section opener.
Shakhtar would have fancied their chances of getting their Group D campaign underway with a win over competition debutants Sheriff on September 15, but goals from Adama Traore and Momo Yansane decided the contest, meaning that there is already pressure on the Ukrainian outfit in the section.
Roberto De Zerbi's side have made a fine start to their domestic campaign, though, picking up 22 points from their nine matches to sit second in the table, and they will enter Tuesday's contest off the back of a 4-1 home success over Veres Rivne on Saturday afternoon.
Shakhtar's run of four straight domestic titles was ended last season by Dynamo Kiev, and they actually finished the campaign without a trophy for the first time since 2014-15. As a result, the Miners started their European campaign in the third qualifying round and had to beat Genk and Monaco to advance to the group stages.
The Ukrainian giants have previous when it comes to advancing deep in this competition, reaching the quarter-finals in 2010-11, but they have been knocked out in the group stage in 11 of their previous 15 participations, and a big effort will be required to finish either first or second in the group.
Shakhtar have only actually won four of their last 20 Champions League fixtures, while they have not beaten Inter in any of their five previous meetings, drawing three and losing two of such encounters.
Inter, meanwhile, suffered a 1-0 loss to Real Madrid in their Group D opener, with Rodrygo's 89th-minute effort proving to be the difference between the two sides at San Siro.
Simone Inzaghi's side are unbeaten in their three matches since the one-goal reverse, though, overcoming Bologna and Fiorentina in the league before sharing the points at home to Atalanta BC on Saturday.
A total of 14 points from six matches has left Inter in third spot in Serie A, two points behind division leaders AC Milan, and the Italian champions will now be hoping to kickstart their Champions League campaign, as it would be seen as a failure if they were unable to advance to the knockout round of the competition.
Inter are the last Italian side to win the Champions League - lifting the trophy in 2010 - but each of their last three campaigns have ended in the group stage; last term, they only managed to win one of their six matches to finish fourth, which also saw them fail to drop into the Europa League.
Shakhtar's Champions League record in terms of victories will concern their fans, but the Nerazzurri have won only three of their last 17 matches in this competition, suffering eight defeats in the process.
Shakhtar will hope to have Mykola Matvienko available for the contest, with the centre-back missing out against Veres at the weekend due to a head injury.
As for Inter, Arturo Vidal, Joaquin Correa, Stefano Sensi and Gabriel Brazao will all miss Tuesday's European contest through injury, but the Italian outfit did not suffer any fresh issues against Atalanta on Saturday.
There are not expected to be any surprises in the away side's XI, with Edin Dzeko again set to join Lautaro Martinez in a front two, while Ivan Perisic and Matteo Darmian should operate as the wing-backs.
Shakhtar Donetsk possible starting lineup:
Pyatov; Dodo, Marlon, Matvienko, Ismaily; Maycon, Antonio; Tete, Pedrinho, Marlos; Traore
Inter Milan possible starting lineup:
Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Brozovic, Calhanoglu, Perisic; Martinez, Dzeko
We say: Shakhtar Donetsk 1-2 Inter Milan
This is a difficult match to call, with both sides under pressure to pick up a result due to their losses on matchday one. We are expecting a tight game in Ukraine but believe that Inter's superior quality, particularly in the final third, will just shine through to help them pick up an important three points.
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