Lithuania vs. Bulgaria (Saturday, 2.00pm)
When the teams meet in Vilnius, the visitors will look to draw level on points with second-placed Switzerland by taking all three points, while their hapless hosts are rock-bottom and still to get off the mark.
We say: Lithuania 1-2 Bulgaria
Bulgaria will complete the double over their Baltic counterparts with a win in Vilnius this weekend; keeping them in with a faint hope of progressing to the playoffs.
A sprinkling of young talent has rejuvenated a stale squad in recent months, so the away side can take the initiative and score at least twice against often obdurate opponents.
Kazakhstan vs. Bosnia H'vina (Saturday, 2.00pm)
While the two nations sit in fourth and fifth place respectively, three points in Nur-Sultan could move them past Ukraine and Finland.
We say: Kazakhstan 1-2 Bosnia-Herzegovina
With neither team having a win to their name thus far, this is a tricky fixture to call. However, Dzeko has been a revelation on the club scene since joining Inter, and we feel that the legendary Bosnian could prove to be the difference at the weekend.
Azerbaijan vs. Rep. Ireland (Saturday, 5.00pm)
The bottom two teams in Group A go head to head for the second time, after playing out a 1-1 draw in Dublin last month.
We say: Azerbaijan 1-1 Republic of Ireland
With a nine-point gap to claw back in just three Group A matches, Republic of Ireland's chances of qualification are extremely slim, and their hopes can only stay alive if they claim all three points on Saturday.
However, we feel that the hosts will frustrate Kenny's side once again and a score draw could be on the cards in Baku.
Georgia vs. Greece (Saturday, 5.00pm)
The visitors are currently third in the section with six points to show from four matches, while Georgia are bottom, having collected just one point from their opening five fixtures.
We say: Georgia 1-2 Greece
Georgia held Greece to a 1-1 draw in the reverse match back in March, and this will not be a straightforward encounter for the visitors. That said, Greece have superior quality all over the field, and we are expecting them to collect all three points in the Group B contest.
Sweden vs. Kosovo (Saturday, 5.00pm)
Janne Andersson's side are currently second in the section with nine points to show from four matches, while Kosovo occupy fourth, having claimed four points from their first five fixtures.
We say: Sweden 2-1 Kosovo
We do not think this will be as comfortable as some are expecting, as Kosovo's squad, and indeed starting XI, will be packed full of talent. That said, Sweden will be desperate to bounce back from their defeat to Greece, and we believe that the home side will have enough to put three points on the board.
Finland vs. Ukraine (Saturday, 5.00pm)
Finland play host to Ukraine on Saturday evening knowing that victory will see them take a significant step towards claiming second position in Group B.
However, Ukraine find themselves in a similar spot, the visitors also being able to move clear of their World Cup qualification rivals with a win in Helsinki.
We say: Finland 1-1 Ukraine
Having avoided defeat in their opening five games, Ukraine will expect to prolong that record in Helsinki. Nevertheless, we are backing the home side to at least earn a share of the spoils, a result which will not necessarily be deemed as a positive ahead of their remaining fixtures.
Scotland vs. Israel (Saturday, 5.00pm)
Scotland welcome Israel to Glasgow's Hampden Park on Saturday evening for the latest round of World Cup 2022 European qualifiers.
The two sides sit second and third in Group F with the hosts just one point above their upcoming opponents in the battle for the second qualification spot.
We say: Scotland 1-0 Israel
With so much at stake, this could be a cagey, low-scoring affair. The reverse fixture back in March ended 1-1 but we are backing Scotland to make the most of home advantage here and secure a narrow victory.
Luxembourg vs. Serbia (Saturday, 7.45pm)
The two nations – who are separated by 66 places in the FIFA world rankings – faced each other in September, with the Orlovi securing a comfortable 4-1 victory on home soil.
We say: Luxembourg 0-3 Serbia
Serbia are still in with a chance of finishing their qualification campaign top of Group A, with a crucial encounter against Portugal to come, so they cannot afford to drop points on Saturday.
The suspension of Rodrigues is a blow for Luxembourg and they may struggle to pose a threat in the final third this weekend, while the visitors have plenty of firepower and as favourites should win comfortably.
Switzerland vs. N. Ireland (Saturday, 7.45pm)
Following a tense goalless draw the last time the nations met, Switzerland host World Cup Qualifying Group C rivals Northern Ireland on Saturday evening.
Separated by just one place and three points in a section dominated by Italy, the clash at Stade de Geneve could prove decisive in settling who will take a probable playoff place and stay in with a shot of reaching Qatar.
We say: Switzerland 2-0 Northern Ireland
After a barren spell across their last two matches, Switzerland can now use their various attacking options to unlock a stubborn Northern Ireland defence; stretching their advantage over the Green and White Army to an irretrievable six points - with another three surely set to follow next week.
Injuries to the visitors' threadbare squad will certainly not help their cause, as they struggle to create clear-cut chances at the best of times and are still lacking real punch up front.
Faroe Islands vs. Austria (Saturday, 7.45pm)
The hosts managed a first win of the campaign in their last game, but still sit three points behind an underperforming Austria side.
We say: Faroe Islands 0-2 Austria
Whilst Austria have been struggling and the Faroe Islands exceeding expectations, we expect the extra quality in the Austrian squad to see them to a comfortable enough victory. After all, the hosts' four points in the group have all come against bottom nation Moldova.
Moldova vs. Denmark (Saturday, 7.45pm)
Moldova welcome Denmark to the Zimbru Stadium in Chisinau on Saturday evening for the latest round of World Cup 2022 European qualifiers.
The two sides sit at opposite ends of Group F with the hosts on just one point and their upcoming opponents having achieved perfection to this point.
We say: Moldova 0-3 Denmark
Denmark conceding their first goal of the campaign to lowly Moldova seems unlikely and, despite probably fielding something of a B-team, it should simply be a matter of how many goals the Danes score.
Andorra vs. England (Saturday, 7.45pm)
The Three Lions have taken 16 points from a possible 18 to sit pretty at the top of the pile, whereas Andorra are second from bottom after a run of largely expected results.
We say: Andorra 0-3 England
Southgate will certainly be tempted to hold some of his big-hitters back for this game, but the likes of Bukayo Saka and Jesse Lingard will have fond memories of their most recent meeting with Andorra.
Alvarez's side may have gone two games without conceding a goal on their own turf, but any chances of a third positive result on the bounce are slim to none - this should be another routine Three Lions victory.
Hungary vs. Albania (Saturday, 7.45pm)
Two sides still harbouring hopes of a second-placed finish in UEFA World Cup 2022 Qualifying Group I meet at the Puskas Arena on Saturday, as Hungary face off against Budapest.
Marco Rossi's side currently occupy fourth spot in the group, while their over-achieving visitors sit second behind England with four games left to go.
We say: Hungary 1-1 Albania
Having been humbled by England on their own turf, Hungary can take nothing for granted against this exciting Albania side with some renowned names in the heart of the rearguard.
Reja has overseen quite the qualification campaign with the visitors, but this game should be as tight as the battle for second place and we are struggling to see a clear winner in Budapest.
Poland vs. San Marino (Saturday, 7.45pm)
Paulo Sousa's men find themselves outside of the top two in Group I after six games, while their visitors will be glad to see the back of yet another doomed qualification campaign.
We say: Poland 5-0 San Marino
Poland boss Sousa ought to take this opportunity to shuffle the pack and give up-and-coming players the chance to stake their claim for further appearances, but there should only be one result come the full-time whistle.
San Marino may have scored a historic goal in their most recent clash with Poland, but the visitors are surely headed for another crushing defeat this weekend.
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