For the third-round tie with Chesterfield, Tuchel made widespread changes to his starting lineup, handing game time to some of the club's squad players and prospects.
However, Tuchel, who has tested positive for coronavirus, has made just one alteration to the team which started the 2-0 victory over Tottenham Hotspur 13 days ago.
Chelsea: Arrizabalaga; Azpilicueta, Christensen, Rudiger, Sarr; Kovacic, Jorginho; Ziyech, Mount, Hudson-Odoi; Lukaku
Subs: Bettinelli, Sharman-Lowe, Alonso, Chalobah, Kenedy, Saul, Barkley, Havertz, Werner
Plymouth Argyle: Cooper; Wilson, Scarr, Gillesphey; Edwards, Camara, Houghton, Mayor, Grant; Jephcott, Garrick
Subs: Burton, Bolton, Broom, Hardie, Ennis, Lewis, Randell, Law, Craske