The 30-year-old has missed his side's last two matches against Aston Villa and Zenit St Petersburg due to an ankle problem.
However, speaking during his pre-match press conference ahead of the clash with Spurs, the Chelsea manager revealed that Kante would be in the squad for the capital derby.
Christian Pulisic, though, remains on the sidelines for the Blues, as the United States international has still not overcome an ankle issue of his own.
"No fresh injury concerns. Christian is trying to come back as fast as possible but is not in the squad. N'Golo is in full shape and ready to play," Tuchel told reporters on Friday afternoon.
Chelsea have won five of their six matches in all competitions this season and will be looking for a third straight success when they take on Nuno Espirito Santo's side. body check tags ::