French midfielder N'Golo Kante has been ruled out after testing positive for coronavirus. The 30-year-old, who is now in self-isolation, will also miss Saturday's Premier League game against Southampton.
Right wing-back Reece James, who was forced off in the first half against Manchester City last weekend with an ankle injury, will not play in Turin.
As a result, Chelsea captain Cesar Azpilicueta is set to replace the 21-year-old, though Callum Hudson-Odoi is also an option, while experienced defender Thiago Silva is expected to join Andreas Christensen and Antonio Rudiger in the back three.
Tuchel is unlikely to make drastic changes to his starting lineup, with the only dilemma for the German being who he decides to start in central midfield.
Goalkeeper Edouard Mendy, who started against Man City after recovering from a knock sustained in training, is expected to start between the sticks ahead of Kepa Arrizabalaga. The Senegalese stopper kept nine Champions League clean sheets last season, the joint-most of any goalkeeper in the competitions' history.
Chelsea possible starting lineup: Mendy; Christensen, T. Silva, Rudiger; Azpilicueta, Kovacic, Jorginho, Alonso; Havertz, Lukaku, Werner